Age-related outcomes in patients with cardiogenic shock str-atified by etiology
Alexander Schmitt1
Kathrin Weidner1
Jonas Rusnak1
Marinela Ruka1
Sascha Egner-Walter1
Kambis Mashayekhi2
Péter Tajti3
Mohamed Ayoub4
Ibrahim Akin1
Michael Behnes1
Tobias Schupp1
1.Department of Cardiology,Angiology,Haemostaseology and Medical Intensive Care,University Medical Centre Mannh-eim,Medical Faculty Mannheim,Heidelberg University,Mannheim,Germany;European Center for AngioScience(ECAS),German Center for Cardiovascular Research(DZHK)partner site Heidelberg/Mannheim,Mannheim,Germany2.Depar-tment of Internal Medicine and Cardiology,Mediclin Heart Centre Lahr,Lahr,Germany3.Gottsegen Gy?rgy National Ca-rdiovascular Center,Budapest,Hungary4.Division of Cardiology and Angiology,Heart Center University of Bochum-Bad Oeynhausen,Bad Oeynhausen,Germany
摘要：BACKGROUND As a result of improved and novel treatment strategies,the spectrum of patients with cardiovascular disease is consistently changing.Overall,those patients are typically older and characterized by increased burden with comorbidities.Limited data on the prognostic impact of age in cardiogenic shock(CS)is available.Therefore,this study investigates the prognostic impact of age in patients with CS.METHODS From 2019 to 2021,consecutive patients with CS of any cause were included.The prognostic value of age(i.e.,60-80 years and>80 years)was investigated for 30-day all-cause mortality.Spearman's correlations,Kaplan-Meier analyses,as well as multivariable Cox proportional regression analyses were performed for statistics.Subsequent risk assessment was performed based on the presence or absence of CS related to acute myocardial infarction(AMI).RESULTS 223 CS patients were included with a median age of 77 years(interquartile range:69-82 years).No significant differe-nce in 30-day all-cause mortality was observed for both age-groups(54.6%vs.63.4%,log-rank P = 0.169;HR = 1.273,95%CI:0.886-1.831,P = 0.192).In contrast,when analyzing subgroups stratified by CS-etiology,AMI-related CS patients of the group>80 years showed an increased risk of 30-day all-cause mortality(78.1%vs.60.0%,log-rank P = 0.032;HR = 1.635,95%CI:1.000-2.673,P = 0.050),which was still evident after multivariable adjustment(HR = 2.072,95%CI:1.174-3.656,P = 0.012).CONCLUSIONS Age was not associated with 30-day all-cause mortality in patients with CS of mixed etiology.However,incre-asing age was shown to be a significant predictor of increased mortality-risk in the subgroup of patients presenting with AMI-CS.
机标关键词：withage-relatedcardiogenicetiologyoutcomespatientsshockstr-atified
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 555-566 )