Current and recent cigarette smoking in relation to cardiov-ascular and non-cardiovascular mortality in an elderly male Chinese population
Wen-Yuan-Yue WANG1
Xiao-Fei YE1
Chao-Ying MIAO1
Wei ZHANG2
Chang-Sheng SHENG2
Qi-Fang HUANG2
Ji-Guang WANG3
1.School of Public Health,Shanghai Jiaotong University School of Medicine,Shanghai,China2.Department of Cardio-vascular Medicine,The Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Jiaotong University School of Me-dicine,Shanghai,China3.School of Public Health,Shanghai Jiaotong University School of Medicine,Shanghai,China;Department of Cardio-vascular Medicine,The Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai Jiaotong University School of Me-dicine,Shanghai,China
摘要：OBJECTIVE To investigate the association between current and former smoking and the risk of mortality in elderly Chinese men.METHODS Our study participants were elderly(≥60 years)men recruited in a suburban town of Shanghai.Cigarette smoking status was categorized as never smoking,remote(cessation>5 years)and recent former smoking(cessation≤5 years),and light-to-moderate(≤20 cigarettes/day)and heavy current smoking(>20 cigarettes/day).Cox proportional hazards models and restricted cubic splines were used to examine the associations of interest.RESULTS The 1568 participants had a mean age of 68.6±7.1 years.Of all participants,311 were never smokers,201 were remote former smokers,133 were recent former smokers,783 were light-to-moderate current smokers and 140 were heavy current smokers.During a median follow-up of 7.9 years,all-cause,cardiovascular and non-cardiovascular deaths occurred in 267,106 and 161 parti-cipants,respectively.Heavy current smokers had the highest risk of all-cause and non-cardiovascular mortality,with an adjusted hazard ratio(HR)of 2.30(95%CI:1.34-4.07)and 3.98(95%CI:2.03-7.83)versus never smokers,respectively.Recent former smo-kers also had a higher risk of all-cause(HR = 1.62,95%CI:1.04-2.52)and non-cardiovascular mortality(HR = 2.40,95%CI:1.32-4.37)than never smokers.Cox regression restricted cubic spline models showed the highest risk of all-cause and non-cardiovascu-lar mortality within 5 years of smoking cessation and decline thereafter.Further subgroup analyses showed interaction between smoking status and pulse rate(≥70 beats/min vs.<70 beats/min)in relation to the risk of all-cause and non-cardiovascular mortality,with a higher risk in current versus never smokers in those participants with a pulse rate below 70 beats/min.CONCLUSIONS Cigarette smoking in elderly Chinese confers significant risks of mortality,especially when recent former sm-oking is considered together with current smoking.
机标关键词：populationrelationchinesecurrentcardiov-ascularcardiovascularcigaretteelderly
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 567-576 )