Prognostic value of hematological parameters in older adu-lt patients with acute coronary syndrome undergoing coro-nary intervention:a single centre prospective study
Umar Hafiz Khan1
Murtaza Rashid Pala2
Imran Hafeez3
Afshan Shabir1
Amrit Dhar4
Hilal Ahmad Rather3
1.Geriatric Medicine,Department of Internal Medicine,Sher-i-Kashmir Institute of Medical Sciences,Srinagar,India2.De-partment of Internal Medicine,Sher-i-Kashmir Institute of Medical Sciences,Srinagar,India3.Department of Cardiology,Sher-i-Kashmir Institute of Medical Sciences,Srinagar,India4.Department of Internal and Pulmonary Medicine,Sher-i-Kashmir Institute of Medical Sciences,Srinagar,India
摘要：BACKGROUND Cardiovascular disease is a significant contributor to the disease burden in geriatric patients.Underlying syste-mic inflammation is thought to be the cause of age-related changes in the bone marrow and a major risk factor for atherosclerosis.The purpose of the study was to assess the accuracy of these hematological biomarkers in predicting 30-day mortality in older patie-nts with acute coronary syndrome(ACS).METHODS This was a prospective observational study of 601 older adult patients(age>60 years)with ACS who underwent per-cutaneous coronary intervention over two years(2017-2019).The relationship between baseline hematological parameters and mo-rtality was assessed during the 30-day follow-up.Logistic regression analysis and receiver operating characteristic curve analysis were done to evaluate for diagnostic accuracy of various hematological parameters.RESULTS The mean age of presentation was 77±17 years.The mean neutrophil-lymphocyte ratio(NLR)value was 5.07±4.90 and the mean platelet-lymphocyte ratio(PLR)value was 108.65±85.82.On univariate analysis,total leucocyte count[odds ratio(OR)= 0.85,P = 0.021],hematocrit(OR = 0.91,P = 0.018),NLR(OR = 1.10,P = 0.001)and PLR(OR = 1.05,P = 0.001)were associated with mo-rtality.On receiver operating characteristic curve analysis,NLR predicted mortality with 68.1%and PLR with 65.7%accuracy.On multivariate analysis,NLR(OR = 1.096,95%CI:1.006-1.15,P = 0.035)was an independent predictor of 30-day mortality.CONCLUSIONS For the risk classification of all elderly ACS patients,we highly advise using NLR rather than the total white blood cell count.
机标关键词：singlestudywithacutecentrecoro-narycoronaryhematological
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 596-601 )