App-based assessment of memory functions in patients after transfemoral aortic valve replacement
Jonathan Nübel1
Michael Hauptmann2
Julika Sch?n3
Georg Fritz4
Christian Butter5
Anja Haase-Fielitz6
1.Department of Cardiology,University Hospital Heart Centre Brandenburg,Brandenburg Medical School(MHB)Theodor Fontane,Bernau,Germany2.Institute of Biostatistics and Registry Research,Brandenburg Medical School Theodor Fontane,Neuruppin,Germany;Faculty of Health Sciences(FGW),Joint Faculty of the University of Pots-dam,the Brandenburg Medical School Theodor Fontane and the Brandenburg Technical University Cottbus-Senften-berg,Cottbus,Germany3.Anesthesia and Intensive Care,University Hospital Ruppin Brandenburg(ukrb),Branden-burg Medical School(MHB)Theodor Fontane,Neuruppin,Germany4.Department of Anesthesiology,Intensive Care and Pain Therapy,University Hospital Heart Centre Brandenburg,Brandenburg Medical School(MHB)Theodor Font-ane,Bernau,Germany5.Department of Cardiology,University Hospital Heart Centre Brandenburg,Brandenburg Medical School(MHB)Theodor Fontane,Bernau,Germany;Faculty of Health Sciences(FGW),Joint Faculty of the University of Pots-dam,the Brandenburg Medical School Theodor Fontane and the Brandenburg Technical University Cottbus-Senften-berg,Cottbus,Germany6.Department of Cardiology,University Hospital Heart Centre Brandenburg,Brandenburg Medical School(MHB)Theodor Fontane,Bernau,Germany;Faculty of Health Sciences(FGW),Joint Faculty of the University of Pots-dam,the Brandenburg Medical School Theodor Fontane and the Brandenburg Technical University Cottbus-Senften-berg,Cottbus,Germany;Institute of Social Medicine and Health System Research,Otto von Guericke University Mag-deburg,Germany
摘要：BACKGROUND Transfemoral aortic valve replacement(TAVR)is the standard treatment for elderly patients with aortic valve stenosis.Although safe and well-established,there is a risk of intraprocedural hemodynamic instability and silent cerebral embolism,which can lead to a decline in neurocognitive function and dementia.In clinical practice,comprehensive cognitive test-ing is difficult to perform.AI-assisted digital applications may help to optimize diagnosis and monitoring.METHODS Neurocognitive function was assessed by validated psychometric tests using"?elta-App",which uses artificial in-telligence and computational linguistic methods for extraction and analysis.Memory function was assessed using the'Consorti-um to Establish a Registry for Alzheimer's Disease'(CERAD)word list and digit span task(DST)before TAVR and before hospit-al discharge.The study is registered in the German Register of Clinical Trials( From October 2020 until March 2022,141 patients were enrolled at University Hospital Heart Centre Brandenburg.Mean age was 81±6 years,42.6%were women.Time between the pre-and post-interventional test was on average 6±3 days.Memory function before TAVR was found to be below average in relation to age and educational level.The pre-post TAVR com-parison showed significant improvements in the wordlist repeat,P<0.001 and wordlist recall test of CERAD,P<0.001.There were no changes in the digital span test.CONCLUSIONS Despite impaired preoperative memory function before TAVR,no global negative effect on memory function after TVAR was detected.The improvements shown in the word list test should be interpreted as usual learning effects in this task.
机标关键词：memoryafteraorticapp-basedassessmentfunctionspatientsreplacement
论文发表日期：2023-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 664-672 )