Association of cumulative resting heart rate exposure with rapid renal function decline:a prospective cohort study with 27,564 older adults
Xi JIANG1
Xian SHAO1
Xing LI2
Pu-Fei BAI1
Hong-Yan LIU1
Jia-Mian CHEN1
Wei-Xi WU1
Zhuang CUI3
Fang HOU4
Chun-Lan LU4
Sai-Jun ZHOU1
Pei YU1
1.NHC Key Laboratory of Hormones and Development,Chu Hsien-I Memorial Hospital and Tianjin Institute of Endo-crinology,Tianjin Medical University,Tianjin,China;Tianjin Key Laboratory of Metabolic Diseases,Tianjin Medical University,Tianjin,China2.NHC Key Laboratory of Hormones and Development,Chu Hsien-I Memorial Hospital and Tianjin Institute of Endo-crinology,Tianjin Medical University,Tianjin,China;Tianjin Key Laboratory of Metabolic Diseases,Tianjin Medical University,Tianjin,China;Ordos Center Hospital,Ordos,Inner Mongolia,Sudu Street,Kangbashi District,Ordos City,China3.Department of Epidemiology and Health Statistics,Tianjin Medical University,Heping District,Tianjin,China4.Community Health Service Center,Jiefang Road,Tanggu Street,Binhai New District,Tianjin,China
摘要：OBJECTIVE To evaluate the prospective association between cumulative resting heart rate(cumRHR)and rapid renal func-tion decline(RRFD)in a cohort of individuals aged 60 and older.METHODS In the Tianjin Chronic Kidney Disease Cohort Study,the individuals who underwent three consecutive physical examinations between 2014 and 2017,with estimated glomerular filtration rate(eGFR)greater than 60 mL/min per 1.73 m2 and aged 60 years or older were enrolled.A total of 27,564 patients were prospectively followed up from January 1,2017 to December 31,2020.The 3-year cumRHR was calculated.The primary outcome was RRFD,defined as an annualized decline in eGFR of 5 mL/min per 1.73 m2 or greater.Logistic and restricted spline regression models and subgroup analysis were used to investigate the association of cumRHR with RRFD after adjusting for all confounders.RESULTS During a median follow-up of 3.2 years,a total of 4,347(15.77%)subjects developed RRFD.In fully-adjusted models,compared with the lowest quartile of cumRHR,the odds ratio(OR)for the highest was 1.44(1.28-1.61),P<0.001.Furthermore,each 1-standard deviation(27.97 beats/min per year)increment in cumRHR was associated with a 17%(P<0.001)increased risk of RRFD,with a linear positive correlation(P for non-linear = 0.803).Participants with a 3-year cumRHR≥207(beats/min)* year(equivalent to≥69 beats/min per year in 3 years)were found to be at a higher risk of RRFD.CONCLUSIONS The cumRHR is significantly associated with a higher risk of RRFD among older adults.These results might provide an effective goal for managing and delaying the decline of renal function in the older adults.
机标关键词：associationexposurefunctionrapidstudyheartwithrate
论文发表日期：2023-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 673-683 )