The impact of aging on cardiac remodeling in chronic mitral regurgitation
David Leibowitz
Donna Zwas
Ronen Beeri
Ronny Alcalai
Israel Gotsman
Heart Institute,Hadassah Medical Center and Faculty of Medicine,Hebrew University of Jerusalem,Jerusalem,Israel
摘要：BACKGROUND Chronic mitral regurgitation(MR)is a volume overload state that causes dilatation of the left sided cardiac chambers.The presence of significant dilatation is considered an indication for mitral valve intervention,however,aging may af-fect left ventricular(LV)remodeling independently of valvular disease.The objective of this study was to examine age-related ch-anges in cardiac remodeling in a broad population of patients with chronic MR.
METHODS Consecutive subjects that underwent echocardiography examinations recorded in the echocardiography database of a university-affiliated laboratory were retrieved.Subjects were categorized into none/mild,moderate or severe MR.For purpo-ses of analysis of differences with aging,the population was divided into groups above and below 70 years of age and standard echocardiographic measurements were compared between the groups.
RESULTS A total of 3492 subjects with at least moderate MR(mean age:76 years,52％female)were included in the study and compared to 18,250 subjects with none or mild MR.Older patients had significantly smaller LV end-diastolic diameters and vol-umes and significantly larger left atrial(LA)volumes when compared to the younger group.LA volume index increased in both age groups as MR severity increased,while LV end-diastolic volume increased with increasing MR only in the younger popula-tion.
CONCLUSIONS Cardiac remodeling in chronic MR is significantly influenced by age.Guideline based recommendations of timing of mitral valve interventions in asymptomatic MR patients,based on assessment of LA and LV remodeling,may need to ta-ke age into account.
机标关键词：impactagingcardiacchronicmitralregurgitationremodeling
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 748-755 )