Lifestyle improvement and the reduced risk of cardiovas-cular disease:the China-PAR project
Ying-Ying JIANG1
Fang-Chao LIU2
Chong SHEN3
Jian-Xin LI2
Ke-Yong HUANG2
Xue-Li YANG4
Ji-Chun CHEN2
Xiao-Qing LIU5
Jie CAO2
Shu-Feng CHEN2
Ling YU6
Ying-Xin ZHAO7
Xian-Ping WU8
Lian-Cheng ZHAO2
Ying LI2
Dong-Sheng HU9
Jian-Feng HUANG2
Xiang-Feng LU2
Dong-Feng GU10
1.Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nan-jing,China;Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Key Laboratory of Cardiovascular Epidemiology,Chinese Academy of Medical Sciences,Beijing,China2.Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Key Laboratory of Cardiovascular Epidemiology,Chinese Academy of Medical Sciences,Beijing,China3.Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nan-jing,China;Research Units of Cohort Study on Cardiovas-cular Diseases and Cancers,Chinese Academy of Medical Sciences,Beijing,China4.Tianjin Key Laboratory of Environ-ment,Nutrition and Public Health;Department of Occupational and Environmental Health,School of Public Health,Tianjin Medical University,Tianjin,China5.Division of Epidemiology,Guangdong Provincial People's Hospital and Cardiovascular Institute,Guangzhou,China6.Department of Cardiology,Fujian Provincial Hospital,Fuzhou,China7.Cardio-Cerebrovascular Control and Research Center,Institute of Basic Medicine,Shandong Academy of Medical Sci-ences,Jinan,China8.Sichuan Center for Disease Control and Prevention,Chengdu,China9.Department of Epidemi-ology and Health Statistics,College of Public Health,Zhengzhou University,Zhengzhou,China;Department of Epi-demiology and Health Statistics,School of Public Health,Shenzhen University Health Science Center,Shenzhen,China10.Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nan-jing,China;Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Key Laboratory of Cardiovascular Epidemiology,Chinese Academy of Medical Sciences,Beijing,China;School of Medicine,Southern University of Science and Technology,Shenzhen,China
摘要：BACKGROUND The benefits of healthy lifestyles are well recognized.However,the extent to which improving unhealthy life-styles reduces cardiovascular disease(CVD)risk needs to be discussed.We evaluated the impact of lifestyle improvement on CVD incidence using data from the China-PAR project(Prediction for Atherosclerotic Cardiovascular Disease Risk in China).
METHODS A total of 12,588 participants free of CVD were followed up for three visits after the baseline examination.Changes in four lifestyle factors(LFs)(smoking,diet,physical activity,and alcohol consumption)were assessed through questionnaires from the baseline to the first follow-up visit.Cox proportional hazard models were used to estimate hazard ratios(HRs)and cor-responding 95%confidence intervals(CIs).The risk advancement periods(RAPs:the age difference between exposed and unex-posed participants reaching the same incident CVD risk)and population-attributable risk percentage(PAR%)were also calcu-lated.
RESULTS A total of 909 incident CVD cases occurred over a median follow-up of 11.14 years.Compared with maintaining 0-1 healthy LFs,maintaining 3-4 healthy LFs was associated with a 40%risk reduction of incident CVD(HR = 0.60,95%CI:0.45-0.79)and delayed CVD risk by 6.31 years(RAP:-6.31[-9.92,-2.70]years).The PAR%of maintaining 3-4 unhealthy LFs was 22.0%compared to maintaining 0-1 unhealthy LFs.Besides,compared with maintaining two healthy LFs,improving healthy LFs from 2 to 3-4 was associated with a 23%lower risk of CVD(HR = 0.77,95%CI:0.60-0.98).
CONCLUSIONS Long-term sustenance of healthy lifestyles or improving unhealthy lifestyles can reduce and delay CVD risk.
机标关键词：projectriskcardiovas-cularchina-pardiseaseimprovementlifestylereduced
论文发表日期：2023-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 779-787 )