Diagnostic performance of intravascular ultrasound-based fractional flow reserve in evaluating of intermediate left main stenosis
Yong-Gang SUI1
Cheng YANG1
Chang-Dong GUAN2
Yan-Lu XU1
Na-Qiong WU1
Wei-Xian YANG1
Yong-Jian WU1
Ke-Fei DOU1
Yue-Jin YANG1
Shu-Bin QIAO1
Wei YU3
Bo XU4
Sheng-Xian TU3
Jie QIAN1
1.Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medic-al Sciences and Peking Union Medical College,Beijing,China2.Catheterization Laboratories,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China3.Biomedical Instrument Institute,School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai,China4.Catheterization Laboratories,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;National Clinical Research Center for Cardiovascular Diseases,Beijing,China
摘要：BACKGROUND The recently introduced ultrasonic flow ratio(UFR),is a novel fast computational method to derive fraction-al flow reserve(FFR)from intravascular ultrasound(IVUS)images.In the present study,we evaluate the diagnostic performance of UFR in patients with intermediate left main(LM)stenosis.
METHODS This is a prospective,single center study enrolling consecutive patients with presence of intermediated LM lesions(diameter stenosis of 30％-80％by visual estimation)underwent IVUS and FFR measurement.An independent core laboratory as-sessed offline UFR and IVUS-derived minimal lumen area(MLA)in a blinded fashion.
RESULTS Both UFR and FFR were successfully achieved in 41 LM patients(mean age,62.0±9.9 years,46.3％diabetes).An ac-ceptable correlation between UFR and FFR was identified(r = 0.688,P<0.0001),with an absolute numerical difference of 0.03(standard difference:0.01).The area under the curve(AUC)in diagnosis of physiologically significant coronary stenosis for UFR was 0.94(95％CI:0.87-1.01),which was significantly higher than angiographic identified stenosis>50％(AUC = 0.66,P<0.001)and numerically higher than IVUS-derived MLA(AUC = 0.82;P = 0.09).Patient level diagnostic accuracy,sensitivity and spe-cificity for UFR to identify FFR≤0.80 was 82.9％(95％CI:70.2-95.7),93.1％(95％CI:82.2-100.0),58.3％(95％CI:26.3-90.4),re-spectively.
CONCLUSION In patients with intermediate LM diseases,UFR was proved to be associated with acceptable correlation and high accuracy with pressure wire-based FFR as standard reference.The present study supports the use of UFR for functional evaluation of intermediate LM stenosis.
机标关键词：diagnosticfractionalultrasoundflowbasedevaluatingintermediateintravascular
论文发表日期：2024-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 34-43 )