Interaction between systemic iron parameters and left ventri-cular structure and function in the preserved ejection fraction population:a two-sample bidirectional Mendelian randomi-zation study
Xiong-Bin MA1
Yong-Ming LIU2
Yan-Lin LV1
Lin QIAN1
1.The First Clinical Medical College of Lanzhou University,Lanzhou,Gansu,China2.Geriatric Cardiovascular Depart-ment and Gansu Clinical Research Center for Geriatric Diseases,First Hospital of Lanzhou University,Gansu,China
摘要：BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is uncertain.This Mendelian randomization(MR)study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction population.
METHODS Transferrin saturation(TSAT),total iron binding capacity(TIBC),and serum iron and ferritin levels were extrac-ted as instrumental variables for iron parameters from meta-analyses of public genome-wide association studies.Individuals without myocardial infarction history,HF,or LV ejection fraction(LVEF)<50％(n = 16,923)in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome dataset.The dataset included LV end-diastolic volume,LV end-systolic volume,LV mass(LVM),and LVM-to-end-diastolic volume ratio(LVMVR).We used a two-sample bidirectional MR study with inverse variance weighting(IVW)as the primary analysis method and estimation methods using different algorithms to improve the robustness of the results.
RESULTS In the IVW analysis,one standard deviation(SD)increased in TSAT significantly correlated with decreased LVMVR(β =-0.1365;95％confidence interval[CI]:-0.2092 to-0.0638;P = 0.0002)after Bonferroni adjustment.Conversely,no significant relationships were observed between other iron and LV parameters.After Bonferroni correction,reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT(β =-0.0699;95％CI:-0.1087 to-0.0311;P = 0.0004).No heterogeneity or pleiotropic effects evidence was observed in the analysis.
CONCLUSIONS We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejec-tion fraction population.
机标关键词：interactionpopulationstructurefractionbetweenfunctionstudybidirectional
论文发表日期：2024-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：17( 64-80 )