Multimorbidity and mortality among older patients with cor-onary heart disease in Shenzhen,China
Fu-Rong LI1
Shuang WANG2
Xia LI1
Zhi-Yuan CHENG1
Cheng JIN1
Chun-Bao MO1
Jing ZHENG2
Feng-Chao LIANG1
Dong-Feng GU3
1.Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine,Southern University of Science and Tech-nology,Shenzhen,Guangdong,China;School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,Guangdong,China2.Shenzhen Health Development Research and Data Manage-ment Center,Shenzhen,China3.Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine,Southern University of Science and Tech-nology,Shenzhen,Guangdong,China;School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,Guangdong,China;School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,China
摘要：BACKGROUND The current understanding of the magnitude and consequences of multimorbidity in Chinese older adults with coronary heart disease(CHD)is insufficient.We aimed to assess the association and population-attributable fractions(PAFs)between multimorbidity and mortality among hospitalized older patients who were diagnosed with CHD in Shenzhen,China.
METHODS We conducted a retrospective cohort study of older Chinese patients(aged≥65 years)who were diagnosed with CHD.Cox proportional hazards models were used to estimate the associations between multimorbidity and all-cause and cardi-ovascular disease(CVD)mortality.We also calculated the PAFs.
RESULTS The study comprised 76,455 older hospitalized patients who were diagnosed with CHD between January 1,2016,and August 31,2022.Among them,70,217(91.9％)had multimorbidity,defined as the presence of at least one of the predefined 14 chronic conditions.Those with cancer,hemorrhagic stroke and chronic liver disease had the worst overall death risk,with adjus-ted HRs(95％CIs)of 4.05(3.77,4.38),2.22(1.94,2.53),and 1.85(1.63,2.11),respectively.For CVD mortality,the highest risk was observed for hemorrhagic stroke,ischemic stroke,and chronic kidney disease;the corresponding adjusted HRs(95％CIs)were 3.24(2.77,3.79),1.91(1.79,2.04),and 1.81(1.64,1.99),respectively.All-cause mortality was mostly attributable to cancer,heart failure and ischemic stroke,with PAFs of 11.8,10.2,and 9.1,respectively.As for CVD mortality,the leading PAFs were heart fail-ure,ischemic stroke and diabetes;the corresponding PAFs were 18.0,15.7,and 6.1,respectively.
CONCLUSIONS Multimorbidity was common and had a significant impact on mortality among older patients with CHD in Shenzhen,China.Cancer,heart failure,ischemic stroke and diabetes are the primary contributors to PAFs.Therefore,prioritizing improved treatment and management of these comorbidities is essential for the survival prognosis of CHD patients from a holist-ic public health perspective.
机标关键词：heartchinawithamongcor-onarydiseasemortalitymultimorbidity
论文发表日期：2024-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 81-89 )