Relationship between mitochondrial respiratory dysfunction of blood mononuclear cells and heart failure severity
Viacheslav A.Korepanov
Tariel A.Atabekov
Tatiana Yu.Rebrova
Roman E.Batalov
Sergey A.Afanasiev
Cardiology Research Institute,Tomsk National Research Medical Center,Russian Academy of Sciences,Tomsk,Russia
摘要：Chronic heart failure(CHF) is a clinical syn-drome manifested by reduced pumping ability of the heart,increased pressure in heart chambers in both physical activity and at rest.The symptoms of this syndrome are dyspnea,un-due fatigability,peripheral edema,which follow structural and functional changes of the myocardi-um.[1] The growing incidence of CHF,especially among elderly people,is an urgent problem for medi-cine in the vast majority of industrialized countries.For instance,in Russian Federation,CHF is diagnosed in about 7 ％of cardiovascular patients.At the same time,this indicator varies from 0.3 ％in young people(20-29 years old) to 70 ％in the older age group.[2,3] A similar trend has been observed in other countries.[4] A wide range of factors influence the development,course,and severity of CHF:systolic function of the heart ventricles,the intensity of myocardial remod-eling,the level of biochemical markers of heart fail-ure(NT-proBNP,galectins,matrix metalloprotein-ases etc.).
机标关键词：relationshipbetweencellsheartblooddysfunctionfailuremitochondrial
论文发表日期：2024-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 130-134 )