Association between the cumulative triglyceride-glucose index and the recurrence of atrial fibrillation after radiofrequency ca-theter ablation
Qing YAN1
Jia-Qi LIANG1
Yi-De YUAN1
Yuan LI1
Jia-Li FAN1
Wen-Huan WU2
Pan XU3
Jia-Hong XUE1
1.Department of Cardiovascular Medicine,the Second Affiliated Hospital of Xi'an Jiaotong University,Shaanxi,China2.Department of Cardiovascular Medicine,Zichang People's Hospital,Shaanxi,China3.Department of Ultrasound,Xi-jing Hospital,Air Force Military Medical University,Shaanxi,China
摘要：BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin resistance.This study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence after radiofrequency cath-eter ablation(RFCA).
METHODS A total of 576 patients with AF who underwent RFCA at the Second Affiliated Hospital of Xi'an Jiaotong Univer-sity were included in this study.The participants were grouped based on cumulative TyG index values tertiles within 3 months after ablation.Cox regression and restricted cubic spline analyses were used to determine the relationship between cumulative TyG index values and AF recurrence.The predictive value of all risk factors was assessed by receiver operating curve analysis.
RESULTS There were 375 patients completed the study(age:63.23±10.73 years,64.27%male).The risk of AF recurrence in-creased with increasing cumulative TyG index values tertiles.After adjusting for potential confounders,patients in the medium cumulative TyG index group[hazard ratio(HR)= 4.949,95%CI:1.778-13.778,P = 0.002]and the high cumulative TyG index gr-oup(HR = 8.716,95%CI:3.371-22.536,P＜0.001)had a higher risk of AF recurrence than those in the low cumulative TyG ind-ex group.The restricted cubic spline regression model also showed an increased risk of AF recurrence with increasing cumulat-ive TyG index values.When considering cumulative TyG index values,left atrial diameter,and lactate dehydrogenase levels as a comprehensive factor,the model could effectively predict AF recurrence after RFCA[area under the curve(AUC)= 0.847,95%CI:0.797-0.897,P＜0.001].
CONCLUSIONS Cumulative TyG index values were a risk factor for AF recurrence after RFCA.Monitoring longitudinal TyG index values may assist with optimized for risk stratification and outcome prediction for AF recurrence.
机标关键词：associationglucosebetweenafterindexablationatrialca-theter
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 200-210 )