Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypert-ensive patients
Luo-Xi XIAO
Zi-Yu WANG
Jiang-Tao LI
Hai-Mei WANG
Yi-Ming HAO
Pan ZHOU
Yu-Lin HUANG
Qiu-Ju DENG
Yong-Chen HAO
Na YANG
Li-Zhen HAN
Zhao YANG
Ping-Ping JIA
Yue QI
Jing LIU
Center for Clinical and Epidemiologic Research,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing Municipal Key Laboratory of Clinical Epidemiology,Beijing,China
摘要：BACKGROUND Hypertension usually clusters with multiple comorbidities.However,the association between cardiometabo-lic multimorbidity(CMM)and mortality in hypertensive patients is unclear.This study aimed to investigate the association betw-een CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with hypertension.
METHODS The data used in this study were from the China National Survey for Determinants of Detection and Treatment Sta-tus of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19-91 years.CMM was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and stroke.Cox proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD mortality.
RESULTS Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one comorbidity.The mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients wit-hout any comorbidity and with one,two,and three or more morbidities,respectively.In the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR = 1.52,95%CI:1.09-2.13)and those with three or more cardiometabolic disea-ses(HR = 2.44,95%CI:1.71-3.48)had a significantly elevated risk of all-cause mortality.The findings were similar for CVD mor-tality but with a greater increase in risk magnitude.
CONCLUSIONS In this study,three-fourths of hypertensive patients had CMM.Clustering with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggest-ing more intensive treatment and control in this high-risk patient group.
机标关键词：associationchinesewithall-causeamongcardiometaboliccardiovasculardisease
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 211-218 )