Effects of loneliness and isolation on cardiovascular diseases:a two sample Mendelian Randomization Study
Jia-Yin CAI
Xin WANG
Cong-Yi ZHENG
Xue CAO
Zhen HU
Run-Qing GU
Yi-Xin TIAN
Ye TIAN
Lan SHAO
Lin-Feng ZHANG
Zeng-Wu WANG
Division of Prevention and Community Health,National Center for Cardiovascular Disease,National Clinical Research Center of Cardiovascular Disease,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,Peking Union Med-ical College&Chinese Academy of Medical Sciences,Beijing,China
摘要：BACKGROUND Loneliness and isolation are associated with multiple cardiovascular diseases(CVDs),but there is a lack of research on whether they were causally linked.We conducted a Mendelian Randomization(MR)study to explore causal relation-ships between loneliness and isolation and multiple CVDs.
METHODS Single nucleotide polymorphisms associated with loneliness and isolation were identified from a genome-wide as-sociation study(GWAS)of 455,364 individuals of European ancestry in the IEU GWAS database.Summary data for 15 CVDs were also obtained from the IEU GWAS database.We used three MR methods including inverse variance weighting,MR-Egger,and weighted median estimation to assess the causal effect of exposure on outcomes.Cochran's Q test and MR-Egger intercept test were used to evaluate the heterogeneity and pleiotropy.
RESULTS MR analysis showed that loneliness and isolation were significantly associated with essential hypertension(OR = 1.07,95%CI:1.03-1.12),atherosclerotic heart disease(OR = 1.04;95%CI:1.02-1.06),myocardial infarction(OR = 1.02;95%CI:1-1.04)and angina(OR = 1.04;95%CI =1.02-1.06).No heterogeneity and pleiotropy effects were found in this study.
CONCLUSIONS Causal relationship of loneliness and isolation with CVDs were found in this study.
机标关键词：isolationsamplestudycardiovasculardiseaseseffectslonelinessmendelian
论文发表日期：2024-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 340-348 )