The diagnostic value of tenascin-C in acute aortic syndrome
Ming MA1
Wei CHEN2
Hai-Long CAO1
Jun PAN1
Qing ZHOU1
Xin-Long TANG1
Dong-Jin WANG1
1.Department of Thoracic and Cardiovascular Surgery,Nanjing Drum Tower Hospital Clinical College of Nanjing Med-ical University,Nanjing,China;Department of Thoracic and Cardiovascular Surgery,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,China2.Department of Thoracic surgery,Kunshan Hospital of Traditional Chinese Medicine,Jiangsu,China
摘要：OBJECTIVES Misdiagnosis of acute aortic syndrome(AAS)significantly increases mortality.Tenascin-C(TN-C)is an extracel-lular matrix glycoprotein related to cardiovascular injury.The elevation of TN-C in AAS and whether it can discriminate sudden-onset of acute chest pain in Chinese remains unclear.
METHODS We measured the plasma concentration of TN-C by ELISA in a cohort of 376 patients with chest or back pain.Measures to discriminate AAS from acute coronary syndrome(ACS)were compared and calculated.
RESULTS From October 2016 to September 2021,376 undiagnosed patients with chest or back pain were enrolled.166 of them were finally diagnosed as AAS,100 were ACS and 110 without cardiovascular diseases(NCV).TN-C was significantly elevated in AAS at 18.18 ng/mL(IQR:13.10-27.68)compared with 7.51 ng/mL(IQR:5.67-11.38)in ACS(P<0.001)and 3.68 ng/mL(IQR:2.50-5.29)in NCV(P<0.001).There was no significant difference in TN-C level among the subtypes of AAS.Of the 166 AAS pa-tients,the peaked level of TN-C was at acute stage(P = 0.012),then a slight of decrease was observed at subacute stage.The area under receiver operating characteristic curve for AAS patients versus NCV was 0.979(95%CI:0.964-0.994)for TN-C.At a cutoff level of 11.474 ng/mL,TN-C has a sensitivity of 76.0%,specificity of 85.5%,accuracy of 82.0%,positive predictive value(PPV)of 76.0%,negative predictive value(NPV)of 85.5%.Diagnostic performance of TN-C was superior to D-dimer and hs-cTnT.
CONCLUSIONS The concentration of serum TN-C in AAS patients was significantly higher than that in ACS patients and NCV.TN-C could be a new biomarker to distinguish AAS patients in the early stage after symptoms onset from other pain dis-eases.
机标关键词：tenascin-cdiagnosticacuteaorticsyndromevalue
论文发表日期：2024-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 359-368 )