The effect of fasting plasma glucose on in-hospital mortal-ity after acute myocardial infarction in patients with and with-out diabetes:findings from a prospective,nationwide,and multicenter registry
Rui FU1
Ying-Xuan ZHU2
Kong-Yong CUI1
Jin-Gang YANG3
Hai-Yan XU3
Dong YIN1
Wei-Hua SONG1
Hong-Jian WANG1
Cheng-Gang ZHU1
Lei FENG1
Wei WU4
Kai-Hong CHEN5
Yan-Yan ZHAO2
Ye LU2
Ke-Fei DOU1
Yue-Jin YANG3
on behalf of the CAMI Registry Investigators
1.Cardiometabolic Medicine Center,Fuwai Hospital,National Center for Cardiovascular Diseases,State Key Laborat-ory of Cardiovascular Disease,National Clinical Research Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China2.Medical Research & Biometrics Center,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medic-al College,Beijing,China3.Coronary Heart Disease Center,Fuwai Hospital,National Center for Cardiovascular Dis-eases,State Key Laboratory of Cardiovascular Disease,National Clinical Research Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China4.Department of Cardiology,Guangzhou Traditional Chinese Medical College First Affiliated Hospital,Guangdong Province,China5.Department of Cardiology,Longyan Hospital First Hospital,Fujian Province,China
摘要：OBJECTIVES To evaluate the predictive value of fasting plasma glucose(FPG)for in-hospital mortality in patients with acute myocardial infarction(AMI)with different glucose metabolism status.
METHODS We selected 5,308 participants with AMI from the prospective,nationwide,multicenter CAMI registry,of which 2,081 were diabetic and 3,227 were nondiabetic.Patients were divided into high FPG and low FPG groups according to the optim-al cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts,respectively.The primary endpoint was in-hospital mortality.
RESULTS Overall,94 diabetic patients(4.5％)and 131 nondiabetic patients(4.1％)died during hospitalization,and the optimal FPG thresholds for predicting in-hospital death of the two cohorts were 13.2 mmol/L and 6.4 mmol/L,respectively.Compared with individuals who had low FPG,those with high FPG were significantly associated with higher in-hospital mortality in diabet-ic cohort(10.1％vs.2.8％;odds ratio[OR]=3.862,95％confidence interval[CI]:2.542-5.869)and nondiabetic cohort(7.4％vs.1.7％;HR=4.542,95％CI:3.041-6.782).After adjusting the potential confounders,this significant association was not changed.Further-more,FPG as a continuous variable was positively associated with in-hospital mortality in single-variable and multivariable models regardless of diabetic status.Adding FPG to the original model showed a significant improvement in C-statistic and net reclassification in diabetic and nondiabetic cohorts.
CONCLUSIONS This large-scale registry indicated that there is a strong positive association between FPG and in-hospital mor-tality in AMI patients with and without diabetes.FPG might be useful to stratify patients with AMI.
机标关键词：plasmaglucoseregistryafterfromacutediabeteseffect
论文发表日期：2024-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 523-533 )