Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope
Bin TU1
Zi-Hao LAI2
Ai-Yue CHEN2
Zhi-Yuan WENG3
Si-Min CAI4
Zhu-Xin ZHANG2
Li-Kun ZHOU2
Li-Hui ZHENG2
Yan YAO2
1.Arrhythmia Center,Fuwai Hospital,National Center for Cardiovascular Diseases,National Key Laboratory,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Cardiac Center,Beijing Chaoyang Ho-spital,Capital Medical University,Beijing,China2.Arrhythmia Center,Fuwai Hospital,National Center for Cardiovascular Diseases,National Key Laboratory,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China3.Cardiovascular Department,The First Affiliated Hospital,Fujian Medical University,Fujian Institute of Hypertension,Fujian,China4.Department of Cardiovascular,The Second Affili-ated Hospital of Zhejiang University School of Medicine,Zhejiang,China
摘要：BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).How-ever,data on different subtypes was scarce.
METHODS This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(36.2％)]with the di-agnosis of VVS.The characteristics among different types of VVS and the outcomes after CNA were analyzed.
RESULTS After a mean follow-up of 4.3±1.5 years,41 patients(29.1％)experienced syncope/pre-syncope events after CNA.Syn-cope/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest re-currence rate after the procedure(n=6,16.7％),followed by mixed(n=26,30.6％)and vasodepressive(n=9,45.0％).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02).Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(P＜0.01).Vasodepressive types with recurrent syncope/pre-syncope after CNA have a lower baseline deceleration capacity(DC)level than those without(7.4±1.0 ms vs.9.0±1.6 ms,P=0.01).Patie-nts with DC＜8.4 ms had an 8.1(HR=8.1,95％CI:2.2-30.0,P=0.02)times risk of syncope/pre-syncope recurrence after CNA com-pared to patients with DC ≥ 8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95％CI:2.2-30.1,P=0.02).
CONCLUSIONS Different subtypes exhibit different event-free rates.The vasodepressive type exhibited the lowest event-free rate,but those patients with DC ≥ 8.4 ms might benefit from CNA.
机标关键词：effectivenessdifferentcardardiablationeurosubtypessyncope
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 651-657 )