The impact of female sex hormones on cardiovascular dise-ase:from mechanisms to hormone therapy
Yi KAN
Yu-Lu PENG
Ze-Hao ZHAO
Shu-Tong DONG
Yin-Xiao XU
Xiao-Teng MA
Xiao-Li LIU
Yu-Yang LIU
Yu-Jie ZHOU
Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart Lung and Blood Vessel Disease,Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease,Clinical Cen-ter for Coronary Heart Disease,Capital Medical University,Beijing,China
摘要：Cardiovascular disease remains the leading cause of mortality in women,yet it has not raised the awareness fr-om the public.The pathogenesis of cardiovascular disease differs significantly between females and males concerning the effect of sex hormones.Estrogen and progestogen impact cardiovascular system through genomic and non-genomic effects.Before menopa-use,cardiovascular protective effects of estrogens have been well described.Progestogens were often used in combination with es-trogens in hormone therapy.Fluctuations in sex hormone levels,particularly estrogen deficiency,were considered the specific ri-sk factor in women's cardiovascular disease.However,considerable heterogeneity in the impact of hormone therapy was observed in clinical trials.The heterogeneity is likely closely associated with factors such as the initial time,administration route,dosage,and formulation of hormone therapy.This review will delve into the pathogenesis and hormone therapy,summarizing the effect of fem-ale sex hormones on hypertension,pre-eclampsia,coronary heart disease,heart failure with preserved ejection fraction,and cardio-vascular risk factors specific to women.
机标关键词：impactfromcardiovasculardise-asefemalehormonesmechanismstherapy
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 669-681 )