Life's essential 8 and risk of subclinical atherosclerosis pro-gression:a prospective cohort study
Shi-Yu ZHOU1
Fang-Chao LIU1
Shu-Feng CHEN1
Jian-Xin LI1
Jie CAO1
Ke-Yong HUANG1
Zheng-Hao TANG1
Feng-Chao LIANG2
Dong-Sheng HU3
Lian-Cheng ZHAO1
Ying LI1
Jian-Feng HUANG1
Xiang-Feng LU1
Bin LU4
Dong-Feng GU5
1.Department of Epidemiology & Key Laboratory of Cardiovascular Epidemiology,State Key Laboratory of Cardiovas-cular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing,China2.School of Public Health and Emergency Management,School of Medi-cine,Southern University of Science and Technology,Shenzhen,China3.Department of Epidemiology and Health Stat-istics,School of Public Health,Zhengzhou University,Zhengzhou,China;Department of Biostatistics and Epidemi-ology,School of Public Health,Shenzhen University Health Science Center,Shenzhen,China4.Department of Radi-ology,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China5.Department of Epidemiology & Key Laboratory of Cardiovascular Epidemiology,State Key Laboratory of Cardiovas-cular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing,China;School of Public Health and Emergency Management,School of Medi-cine,Southern University of Science and Technology,Shenzhen,China
摘要：BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH)in reducing cardiovas-cular risk.However,its role in subclinical atherosclerosis(SA)progression remains unclear.We aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of SA.
METHODS This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for 5.7 years.The LE8 score(range,0-100)consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008-2009.Progression of SA was determined by carotid plaque and coronary artery calcification(CAC)in 2008-2009 and 2013-2014.Log-binomial regression model was used to estimate the associ-ation of LE8 score with SA progression.
RESULTS Each 10 points increment in LE8 score was associated with 15.2％(RR:0.848,95％CI:0.797-0.902),17.7％(RR:0.823,95％CI:0.766-0.884)and 12.0％(RR:0.880,95％CI:0.845-0.916)lower risks of carotid plaque,CAC and overall SA progression,respectively.Compared with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had 39.1％(RR:0.609,95％CI:0.494-0.752),41.0％(RR:0.590,95％CI:0.456-0.764)and 29.7％(RR:0.703,95％CI:0.598-0.825)lower risks of carotid plaque,CAC and overall SA progression,respectively.
CONCLUSIONS Higher LE8 scores were associated with lower risks of SA progression.Besides,long-term maintenance of op-timal CVH was more beneficial to prevent SA progression.
机标关键词：studyrisklifeatherosclerosiscohortessentialpro-gressionprospective
论文发表日期：2024-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 751-759 )