Mental disorders after myocardial infarction:potential me-diator role for chemokines in heart-brain interaction?
Parth Patel1
Feiyan Yang2
Dumitru A.Iacobas3
Lei Xi4
1.Department of Biology,College of Humanities and Sciences,Virginia Commonwealth University,Richmond,VA,USA2.Department of Cardiology,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China3.The Texas Undergraduate Medical Academy,Prairie View A & M Univer-sity,Prairie View,TX,USA4.Pauley Heart Center,Division of Cardiology,Department of Internal Medicine,School of Medicine,Virginia Commonwealth University,Richmond,VA,USA
摘要：Acute myocardial infarction(MI)remains one of the leading causes of mortality and morbidity in the global communities.A pre-vailing topic that has attracted increasing attentions over the past few decades is the so-called heart-brain interaction,in particu-lar following a major traumatic event such as MI.Increased prevalence of depression and other mental disorders has been recog-nized in cardiac patients after MI,coronary catheterization,or cardiothoracic surgeries.In this review,we focus on the potential pathogenic mechanisms and pre-clinical transcriptomic evidence for identifying potential mediators of post-MI depression.We first summarize the conventional mechanistic understanding that leads to the current clinical management of post-MI depression with the use of selective serotonin reuptake inhibitors(SSRIs)and cognitive behavior and exercise therapies.We further envisage a possible role played by certain chemokines,e.g.,Chemokine(C-X-C motif)ligand 12(CXCL12)and Chemokine(C-C motif)lig-and 2(CCL22),in serving as signaling molecules to connect the MI-induced heart damage to the pro-depressive changes in brain during the post-MI period.Future in-depth investigations into this chemokine hypothesis will be instrumental in developing new chemokine-targeted therapies for better management of the cardiac patients suffering from post-MI depression.
机标关键词：interactionafterrolechemokinesdisordersheart-braininfarctionme-diator
论文发表日期：2024-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 913-926 )