Cardiometabolic and panvascular multimorbidity associated with motoric cognitive risk syndrome in older adults
Rui SHE1
Zhong-Rui YAN2
Peng WANG2
Ya-Jun LIANG3
Cheng-Xuan QIU4
1.Department of Rehabilitation Sciences,the Hong Kong Polytechnic University,Hong Kong,China2.Department of Ne-urology,Jining No.1 People's Hospital,Jining,China3.Department of Global Public Health,Karolinska Institutet,Stock-holm,Sweden4.Aging Research Center and Center for Alzheimer Research,Department of Neurobiology,Care Sciences and Society,Karolinska Institutet-Stockholm University,Stockholm,Sweden;Department of Neurology,Shandong Pr-ovincial Hospital Affiliated to Shandong First Medical University,Jinan,China
摘要：Background Motoric cognitive risk(MCR)syndrome as a pre-dementia syndrome often co-occurring with chronic health condi-tions.This study aims to investigate the prevalence of MCR and its association with cardiometabolic and panvascular multimorb-idity among older people living in rural China.
Methods This population-based study included 1450 participants who were aged＞60 years(66.2％women)and who underto-ok the second wave examination of the Confucius Hometown Aging Project in Shandong,China when information to define MCR was collected.Data were collected through in-person interviews,clinical examinations,and laboratory tests.Cardiometabolic and pa-nvascular multimorbidity were defined following the international criteria.MCR was defined as subjective cognitive complaints and slow gait speed in individuals free of dementia and functional disability.Multivariable logistic regression models were used to exa-mine the associations of MCR with multimorbidity.
Results MCR was present in 6.3％of all participants,and the prevalence increased with advancing age.Cerebrovascular disea-se,ischemic heart disease,heart failure,and increased serum cystatin C were associated with increased likelihoods of MCR(mult-ivariable-adjusted odds ratio range:1.90-3.02,P＜0.05 for all).Furthermore,there was a dose-response relationship between the nu-mber of cardiometabolic diseases and panvascular diseases and the likelihood of MCR.The multivariable-adjusted odds ratio(95％CI)of MCR associated with cardiometabolic and panvascular multimorbidity were 2.47(1.43-4.26)and 3.85(2.29-6.47),respectiv-ely.
Conclusions Older adults with cardiometabolic and panvascular multimorbidity are at a higher likelihood of MCR.These fin-dings may have implications for identifying older adults at pre-dementia state as targets for early preventive interventions to delay dementia onset.
机标关键词：cognitiveriskwithadultsassociatedcardiometabolicmotoricmultimorbidity
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 944-953 )