Potential role of peripheral blood mononuclear cell's mitoch-ondrial respiratory dysfunction in heart failure severity predi-ction in patients with cardioverter-defibrillator implantation indications
Tariel A Atabekov
Sergey N Krivolapov
Mikhail S Khlynin
Viacheslav A Korepanov
Tatiana Yu Rebrova
Elvira F Muslimova
Sergey A Afanasiev
Roman E Batalov
Sergey V Popov
Cardiology Research Institute,Tomsk National Research Medical Center,Russian Academy of Sciences,Tomsk,Russia
摘要：Background It has been reported that the mitochondrial respiratory dysfunction(MRD)is important mechanisms affecting the heart failure(HF)pathogenesis.We sought to evaluate the potential role of MRD of peripheral blood mononuclear cells(PBMC)in HF severity prediction in patients with cardioverter-defibrillator implantation indications.
Methods In this single-center study patients with HF of New York Heart Association(NYHA)Ⅰ-Ⅲ functional class(FC)and ca-rdioverter-defibrillator implantation indications underwent transthoracic echocardiography(TTE)and MRD assessment using PB-MC.Mitochondrial respiration rate(MRR)indicators(pyruvate+malate+adenosine diphosphate;succinate+adenosine diphos-phate;pyruvate+malate-adenosine diphosphate[V4.1];succinate-adenosine diphosphate)were calculated.Correlations betwe-en HF NYHA FC,TTE and MRR indicators were evaluated.Based on our data,we developed a risk model regarding HF severi-ty.
Results Of 53(100.0％)HF patients,33(62.3％)had mild exercise intolerance(1st group)and 20(37.7％)had moderate-to-severe ex-ercise intolerance(2nd group).Patients with mild exercise intolerance were likely to have a higher V4.1(P＜0.001)values.V4.1 was ind-ependently associated with moderate-to-severe exercise intolerance in univariate and multivariate logistic regression(OR=0.932,95％CI:0.891-0.975,P＜0.001).
Conclusions The severity of HF is associated with PBMC mitochondrial respiratory dysfunction in patients with cardioverter-de-fibrillator implantation indications.Our HF severity risk model including V4.1 parameters is able to distinguish patients with mild and moderate-to-severe exercise intolerance.Further investigations of their predictive significance are warranted.
机标关键词：heartbloodrolecellwithcardioverterdefibrillatordysfunction
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 981-991 )