Association of handgrip strength with aortic stenosis among adults aged 60 years and older:evidence from the 157097 UK Biobank participants
Cheng-Xiang SONG1
Qing LI2
Cong-Ying XIA3
Lu LONG4
Xiao-Xi ZENG5
Jun-Li LI6
Mao CHEN1
1.Laboratory of Cardiac Structure and Function,Institute of Cardiovascular Diseases,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China;Department of Cardiology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China2.Laboratory of Cardiac Structure and Function,Institute of Cardiovascular Diseases,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China;National Clinical Research Center for Geriatrics,the Center of Gerontology and Geriatrics,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China3.Department of Cardiology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China4.Department of Epidemi-ology and Health Statistics,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,Sichuan Province,China5.West China Biomedical Big Data Center,West China Hospital,Sichuan Uni-versity,Chengdu,Sichuan Province,China;Division of Nephrology,Kidney Research Institute,West China hospital,Sichuan University,Chengdu,Sichuan Province,China6.Laboratory of Cardiac Structure and Function,Institute of Cardiovascular Diseases,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China
摘要：Objective To examine the association of handgrip strength with aortic stenosis incidence among adults aged 60 years and older.
Methods We conducted a cohort study using the UK Biobank data to assess the relationship between handgrip strength and in-cident aortic stenosis in individuals aged 60 years and older.Handgrip strength was measured using a Jamar J00105 hydraulic hand dynamometer.Adjusted Cox proportional hazards regression models were conducted to assess the association between handgrip strength and incident aortic stenosis.
Results We included 157,097 UK Biobank participants(78,151 women and 78,946 men)in our study,with mean age of 64±2.9 years.During a median follow-up of 8.1(7.4-8.8)years,1543(1.0％)participants developed incident aortic stenosis.Compared with those with the lowest handgrip strength(tertile 1),the adjusted hazard ratios(95％confidence interval)of incident aortic stenosis in the middle(tertile 2)and the highest(tertile 3)were 0.86(0.77-0.97)and 0.76(0.67-0.87),respectively.
Conclusions Higher handgrip strength was associated with lower risk of developing aortic stenosis in older adults.Future studies warrant preventive strategies for older adults with lower handgrip strength.
机标关键词：associationbiobankwithfromadultsagedamongaortic
论文发表日期：2024-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1026-1033 )