The role of acetazolamide in critical care and emergency me-dicine
Jacopo Davide Giamello1
Gabriele Savioli2
Yaroslava Longhitano3
Fiorenza Ferrari4
Salvatore D'Agnano1
Ciro Esposito5
Manfredi Tesauro6
Christian Zanza7
1.Department of Emergency Medicine,Azienda Ospedaliera S.Croce e Carle,Cuneo,Italy2.Emergency Medicine and Surgery,IRCCS Fondazione Policlinico San Matteo,Pavia,Italy3.Department of Anesthesiology and Perioperative Medicine,University of Pittsburgh,Pittsburgh,PA 15260,USA;Department of Emergency Medicine-Emergency Medicine Residency Program,Humanitas University-Research Hospital,20089 Rozzano,Italy4.International Renal Re-search Institute of Vicenza(IRRIV),Department of Nephrology,Dialysis and Transplantation,San Bortolo Hospital,Azienda ULSS;8.Berica,Vicenza,Italy;Department of Anaesthesia,Critical Care and Emergency,Foundation IRCCS Ca'Granda Ospedale Maggiore Policlinico,Milan,Italy5.Unit of Nephrology and Dialysis,ICS Maugeri,University of Pavia,Pavia,Italy6.Department of Systems Medicine,University of Rome"Tor Vergata",Rome,Italy;Geriatric Medicine Residency Program,University of Rome"Tor Vergata",Rome,Italy7.Geriatric Medicine Residency Program,University of Rome"Tor Vergata",Rome,Italy
摘要：Acetazolamide is the commonly prescribed oral and intravenous carbonic anhydrase inhibitor;over the years,its use in clinical practice has decreased in favor of more recent drugs.However,it is a rather handy drug,which can be useful in several clinical settings when managing critically ill patients.The objective of this review is the evaluation of the most recent evidence on the use of acetazolamide in emergency medicine and critical care medicine.Furthermore,the safety profile of this drug has been evalu-ated.This is a narrative review on the use of acetazolamide in the main contexts in which this drug can be useful in emergency situations for patients with potential critical issues.For the timeline 1999-2024,a search was conducted on the main scientific plat-forms;resources of greatest relevance for the use of acetazolamide in critical care and emergency medicine were selected.The most common emergency situations in which a critically ill patient could benefit from acetazolamide therapy are acute heart fail-ure,acute mountain sickness,post hypercapnic metabolic alkalosis,idiopathic intracranial hypertension and acute angle-closure glaucoma.In a few cases,however,randomized controlled clinical trials have been conducted.There are also other less solid in-dications based mostly on experience or retrospective data.Acetazolamide seems to be an overall safe drug;serious side effects are rare and can be avoided by carefully selecting the patients to be treated.Acetazolamide represents a precious resource for emergency physicians and intensivists;critical patients with different conditions can in fact benefit from it;furthermore,acetazol-amide is a safe drug if administered to correctly selected patients.
机标关键词：rolecareacetazolamidecriticalemergencyme-dicine
论文发表日期：2024-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 1085-1095 )