Radiomics of baseline epicardial adipose tissue predicts left ventricular mass regression after transcatheter aortic valve replace-ment
Yi ZHANG1
Hao-Ran YANG2
Xing-Yu JI2
Tian-Yuan XIONG1
Mao CHEN1
1.Department of Cardiology,West China Hospital,Sichuan University,Chengdu,China;Cardiac Structure and Func-tion Research Key Laboratory of Sichuan Province,West China Hospital,Sichuan University,Chengdu,China2.Department of Cardiology,West China Hospital,Sichuan University,Chengdu,China
摘要：Background Epicardial adipose tissue(EAT)radiomics derived from cardiac computed tomography(CT)images may pr-ovide insights into EAT characteristics,which can further predict regression of left ventricular mass index(LVMI)after transcath-eter aortic valve replacement(TAVR).This study aimed to develop and validate a radiomics nomogram based on pre-procedural EAT CT to predict inadequate LVMI regression following TAVR.
Methods Inadequate LVMI regression was defined as △LVMI％＜15％at one-year post TAVR.Radiomics features from pre-procedural CT images were selected mainly by least absolute shrinkage and selection operator algorithm.The patients were ran-domly divided into the training and validation cohorts to establish and evaluate three feature classifier models based on the selec-ted features,using which the Radiomics scores(Radscores)were then calculated.A radiomics nomogram was constructed using independent risk factors and further assessed using area under the curve,calibration curve,and decision curve analysis.
Results A total of 144 consecutive TAVR patients(42 patients with inadequate and 102 patients with adequate LVMI regres-sion)were randomly assigned to the training and validation cohorts(116 patients and 28 patients,respectively).A total of 1130 radiomics features from each patient yielded 6 features for the Radscore construction after selection,with logistic regression and support vector machine models favored.Subsequently,a nomogram based solely on the Radscore was constructed,with an area under the curve of 0.743 in the validation cohort,along with favorable decision curve analysis and calibration curves.
Conclusions The developed radiomics nomogram,serving as a non-invasive tool,achieved satisfactory preoperative predic-tion of inadequate LVMI regression in TAVR patients,thereby facilitating clinical management.
机标关键词：baselinetissueaftermassadiposeaorticepicardialleft
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1109-1118 )