One-year clinical events according to frailty in older patients with non-ST elevation acute coronary syndrome undergoing coronary angiography:an analysis of the IM PACT-TIMING-GO study
Pablo Díez-Villanueva1
Pedro Cepas-Guillén2
María Thiscal López Lluva3
Alfonso Jurado-Román4
Pablo Bazal-Chacón5
Martín Negreira-Caamaño6
Iván Olavarri-Miguel7
Ane Elorriaga8
Ricardo Rivera-López9
David Escribano10
Pablo Salinas11
María Martínez-Avial1
Antonio Martínez-Guisado2
Clea González-Maniega3
Felipe Díez-Delhoyo6
1.Servicio de Cardiología,Hospital Universitario de La Princesa,Madrid,Spain2.Servicio de Cardiología,Hospital Clinic,Barcelona,Spain3.Servicio de Cardiología,Hospital Universitario de León,León,Spain4.Servicio de Cardio-logía,Hospital La Paz,Madrid,España IdiPaz(Instituto de Investigación Sanitaria del Hospital Universitario La Paz).Madrid,Spain5.Servicio de Cardiología,Complejo Hospitalario de Navarra,Pamplona,Navarra,Spain6.Servicio de Cardiología,Hospital Universitario;12.Octubre,Madrid,Spain7.Servicio de Cardiología,Hospital Marqués de Val-decilla,Santander,Cantabria,Spain8.Servicio de Cardiología,Hospital Universitario de Basurto,Bilbao,Vizcaya,Spain9.Servicio de Cardiología,Hospital Virgen de las Nieves,Granada,Spain10.Servicio de Cardiología,Hospital Universitario San Juan de Alicante,San Juan de Alicante,Spain11.Servicio de Cardiología,Instituto de Investigación Sanitaria del Hospital Clínico San Carlos(IdISSC),Madrid,Spain
摘要：Objective To evaluate the prevalence and one-year prognosis associated with frailty in a contemporary cohort of older patients with non-ST-elevation acute coronary syndrome(NSTEACS).
Methods The IMPACT-TIMING-GO registry(IMPACT of Time of Intervention in patients with Myocardial Infarction with Non-ST seGment elevation.ManaGement and Outcomes)prospectively included 1020 patients with NSTEACS undergoing invas-ive coronary angiography between April and May 2021.For this sub-study,patients ≥ 65 years were selected.Frailty was as-sessed according to FRAIL scale.We studied all-cause mortality and the composite of all-cause mortality or all-cause hospitaliza-tions at one-year follow-up after discharge.
Results Five hundred and sixty seven patients(mean age:75.8±6.7 years,28.2％women)were included:316(55.7％)were ro-bust,183(32.3％)prefrail,and 68(12.0％)frail.Frail patients were significantly older,more often women,and presented a worse baseline clinical profile.There were no differences among groups regarding pretreatment with a P2Y12 inhibitor.An urgent an-giography(＜24 h)was less frequently performed in frail patients,with no differences regarding revascularization approach or in main in-hospital adverse events,although acute kidney disease occurred more frequently in frail patients.At 1-year follow-up,20 patients died(3.6％).Chronic kidney disease was independently associated with 1-year all-cause death,although a trend towards higher mortality was observed in frail patients(HR=3.01;95％CI:0.93-9.78;P=0.065).Frailty was independently associated with higher 1-year all-cause mortality or all-cause rehospitalizations(HR=2.23;95％CI:1.43-3.46;P＜0.001)
Conclusions In older patients with NSTEACS,frailty independently associates higher all-cause mortality or all-cause hospital admissions at one-year follow-up.
机标关键词：angiographyanalysisclinicalstudywithaccordingacutecoronary
论文发表日期：2025-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 159-168 )