Additional role of low-density lipoprotein cholesterol on the risk of osteoporosis in men with or without coronary heart dis-ease:a real-world longitudinal study
Jing ZENG1
Zi-Mo PAN2
Ting LI3
Ze-Yu CHEN4
Xiao-Yan CAI5
Mei-Liang GONG6
Xin-Li DENG6
Sheng-Shu WANG7
Nan LI3
Miao LIU8
Chun-Lin LI1
1.Department of Endocrinology,the Second Medical Center and National Clinical Research Center for Geriatric Dise-ase,Chinese PLA General Hospital,Beijing,China;National Key Laboratory of Kidney Disease,Chinese PLA Gener-al Hospital,Beijing,China2.Department of Endocrinology,the Second Medical Center and National Clinical Research Center for Geriatric Dise-ase,Chinese PLA General Hospital,Beijing,China;Graduate School of Chinese PLA General Hospital,Beijing,China3.Department of Endocrinology,the Second Medical Center and National Clinical Research Center for Geriatric Dise-ase,Chinese PLA General Hospital,Beijing,China4.School of Basic Medi-cine,Army Medical University,Chongqing,China5.Department of Nephrology,the Second Medical Center and Nat-ional Clinical Research Center for Geriatric Disease,Chinese PLA General Hospital,Beijing,China6.Department of Clin-ical Laboratory,the Second Medical Center and National Clinical Research Center for Geriatric Disease,Chinese PLA Ge-neral Hospital,Beijing,China7.Institute of Geriatrics,Beijing Key Laboratory of Elderly Comorbidities,the Second Med-ical Center and National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing,China8.National Key Laboratory of Kidney Disease,Chinese PLA Gener-al Hospital,Beijing,China;Department of Anti-NBC Medicine,Graduate School of Chinese PLA General Hospital,Beijing,China
摘要：BACKGROUND Early control of low-density lipoprotein cholesterol(LDL-C)is crucial for reducing the progress of cardiovascular disease.However,its additional role to the risk of primary osteoporosis in men with coronary heart disease was inconclusive.Our study aims to determine the association of LDL-C and its trajectories for osteoporosis risk in the middle-aged and aged men of China.
METHODS The retrospective cohort study of 1546 men aged 69.74±11.30 years conducted in Beijing,China from 2015 to 2022.And the incidence of primary osteoporosis was annually recorded.LDL-C trajectories were further identified by latent class growth model using repeated measurements of LDL-C.The association of baseline LDL-C for osteoporosis was estimated using hazard ratio(HR)with 95％CI in Cox proportional hazard model,while mean level and trajectories of LDL-C for osteoporosis were evaluated using odds ratio(OR)with 95％CI in logistic regression model.
RESULTS During the median 6.2-year follow-up period,70 men developed primary osteoporosis.The higher level of baseline LDL-C(HR=1.539,95％CI:1.012-2.342)and mean LDL-C(OR=2.190,95％CI:1.443-3.324)were associated with higher risk of osteoporosis in men with coronary heart disease after adjusted for covariates.Compared with those in the LDL-C trajectory of low-stable decrease,participants with medium-fluctuant trajectory,whose longitudinal LDL-C started with a medium LDL-C level and appeared an incr-ease and then decrease,were negatively associated with osteoporosis risk(OR=2.451,95％CI:1.152-5.216).And participants with init-ially high LDL-C level and then a rapid decrease demonstrated a tendency towards reduced risk(OR=0.718,95％CI:0.212-2.437).
CONCLUSIONS Elevated LDL-C level and its long-term fluctuation may increase the risk of primary osteoporosis in men.Early co-ntrolling a stable level of LDL-C is also essential for bone health.
机标关键词：heartstudyriskroleadditionalcholesterolcoronarydis-ease
论文发表日期：2025-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 219-228 )