Clinical implication of post-angioplasty quantitative flow ratio in the patients with coronary artery de novo lesions under-went drug-coated balloons treatment
Yun-Hui ZHU
Xu-Lin HONG
Tian-Li HU
Qian-Qian BIAN
Yu-Fei CHEN
Tian-Ping ZHOU
Jing LI
Guo-Sheng FU
Wen-Bin ZHANG
Department of Cardiology,Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,China
摘要：Background Quantitative flow ratio(QFR)holds significant value in guiding drug-coated balloon(DCB)treatment and enhan-cing outcomes.However,the predictive capability of post-angioplasty QFR for long-term clinical events in patients with de novo lesions who receive DCB treatment remains uncertain.The aim of this study was to explore the potential significance of post-an-gioplasty QFR measurements in predicting clinical outcomes in patients underwent DCB treatment for de novo lesions.
Methods Patients who underwent DCB-only intervention for de novo lesions were enrolled.QFR was conducted after DCB treatment.The patients were then categorized based on post-angioplasty QFR.The primary endpoint was major adverse cardiac events(MACE),encompassing all-cause death,cardiovascular death,nonfatal myocardial infarction,stroke,and target vessel re-vascularization.
Results A total of 553 patients with 561 lesions were included.The median follow-up period was 505 days,during which 66(11.8%)MACEs occurred.Based on post-procedural QFR grouping,there were 259 cases in the high QFR group(QFR>0.93)and 302 cases in the low QFR group(QFR≤0.93).Kaplan-Meier analysis revealed a significantly higher cumulative incidence of MACE in the low QFR group(log-rank P=0.004).The multivariate Cox proportional hazards model demonstrated a significant inverse correlation between QFR and the occurrence of MACEs(HR=0.522,95%CI:0.289-0.942,P=0.031).Landmark analysis in-dicated that high QFR had a significant reducing effect on the cumulative incidence of MACEs within 1 year(log-rank P=0.016)and 1-5 years(log-rank P=0.026).
Conclusions In patients who underwent DCB-only treatment for de novo lesions,higher post-procedural QFR values(>0.93)were identified as an independent protective factor against adverse prognosis.
机标关键词：quantitativeangioplastyclinicalpostflowwitharteryballoons
论文发表日期：2025-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 332-343 )