Global,regional,and national burden of ischemic heart dis-ease attributable to metabolic risks:a systematic analysis of Global Burden of Disease 2021
Bo-Qing LIU1
Chang YANG1
Heng-Yang WEI1
Zai-Xin YU2
1.Department of Clinical Medicine,Xiangya Medical School,Central South University,Changsha,China2.Depart-ment of Cardiology and National Clinical Research Center for Geriatric Disorders,Xiangya Hospital Central South Uni-versity,Changsha,China
摘要：Background Ischemic heart disease(IHD)represents the most significant disease burden among all cardiovascular diseases(CVDs).The increasing prevalence of metabolic risks in the 21st century has a profound impact on the disease burden associated with IHD.We analyzed the global,regional,and national burdens of IHD attributable to metabolic risks from 1990 to 2021.
Methods The data were taken from Global Burden of Disease(GBD)study 2021.Deaths,disability-adjusted life years(DALYs),the average annual percent change(AAPC),age-standardized death rates per 100,000 persons(ASDR)and age-standardized rate per 100,000 persons(ASR)of DALYs ranging from 1990 to 2021,were extracted and stratified according to region,nationality,so-cio-demographic index(SDI),sex,and age.Additionally,the global future trends were predicted using Nordpred prediction model.
Results Compared to 1990,in 2021,the number of death and DALYs from metabolic risk-attributed IHD increased globally by 67.35%and 59.91%,respectively;whereas ASDR and ASR of DALYs showed a decreasing trend and the most severe impact was observed in male and elderly populations.In addition,the burden of disease showed an inverted V-shaped relationship with SDI from 1990 to 2021.AAPC showed a significant increase in developing countries and a decrease in developed countries.We also analyzed the effects of different risk factors including metabolic risk factors on IHD in different SDI regions and genders.The pre-diction of future disease burden showed that the number of death and DALYs will keep rising,while ASDR and ASR of DALYs will maintain a certain downward trend.
Conclusions The results of this study highlighted the need for screening and intervention for metabolic risk factors in specific regions and populations,this should call for increased collaboration between developing and developed countries to reduce the burden of disease and improve the prognosis of patients with IHD.
机标关键词：metabolicglobalnationalregionalanalysisrisksheartattributable
论文发表日期：2025-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：20( 361-380 )