The relationship between geriatric nutritional risk index and cardiovascular disease and all-cause mortality in patients wi-th osteoporosis and osteopenia
Sheng-Han WANG1
Hang YIN2
Shan-Shan ZHOU1
1.Department of Cardiovascular Center,The First Hospital of Jilin University,Changchun,China2.Department of On-cology,The First Affiliated Hospital of Dalian Medical University,Dalian,China
摘要：BACKGROUND The correlation between geriatric nutritional risk index(GNRI)and the prognosis of patients with osteoporo-sis or osteopenia has not been studied.This study aims to explore the relationship between GNRI and the cardiovascular disease(CVD)and all-cause mortality rates in elderly patients with osteoporosis or osteopenia.
METHODS This study included 4756 patients with osteoporosis and osteopenia from five cycles of the National Health and Nu-trition Examination Survey(NHANES).We used multivariable Cox regression and subgroup analyses to investigate the correlati-on between GNRI and mortality rates.The restricted cubic spline analysis was used to assess the dose-response relationship betw-een GNRI and mortality risk.Mediation analysis was conducted to examine the mediating effect of chronic kidney disease on the relationship between nutritional risk and mortality.
RESULTS During a median follow-up period of 114 months,a total of 1241 deaths(26.09%)occurred,including 300 deaths due to CVD(6.31%).In the fully adjusted Model 3,compared to the no-risk group,the risk group showed significantly increased all-ca-use mortality risk(HR=2.05,95%CI:1.74-2.40)and CVD mortality risk(HR=1.88,95%CI:1.30-2.71).The restricted cubic spline analysis indicated a non-linear association between GNRI and all-cause mortality risk as well as CVD mortality risk.The media-tion analysis results indicated that chronic kidney disease mediates 16.9%of the effect of nutritional risk on all-cause mortality and 25.3%on CVD mortality risk.
CONCLUSIONS GNRI can serve as a predictive factor for all-cause and CVD mortality rates in elderly patients with osteopor-osis or osteopenia.
机标关键词：relationshipbetweenindexriskall-causecardiovasculardiseasegeriatric
论文发表日期：2025-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 443-454 )