Impact of admission-blood-glucose-to-albumin ratio on all-cause mortality and renal prognosis in critical patients with co-ronary artery disease:insights from the MIMIC-Ⅳ database
Yong HONG1
Bo-Wen ZHANG1
Jing SHI1
Ruo-Xin MIN1
Ding-Yu WANG1
Jiu-Xu KAN1
Yun-Long GAO1
Lin-Yue PENG1
Ming-Lu XU1
Ming-Ming WU2
Yue LI3
Li SHENG1
1.Harbin Medical University,Harbin,China;Department of Cardiology,the First Affiliated Hospital of Harbin Medic-al University,Harbin,China2.Harbin Medical University,Harbin,China;Departments of Cardiology and Critical Care Medicine,the First Affiliated Hospital of Ha-rbin Medical University,NHC Key Laboratory of Cell Transplantation,Key Laboratories of Education Ministry for Myoc-ardial Ischemia Mechanism and Treatment,Harbin,China3.Harbin Medical University,Harbin,China;Department of Cardiology,the First Affiliated Hospital of Harbin Medic-al University,Harbin,China;Heilongjiang Province Clinical Medical Research Center for Hypertension,the First Affiliated Hospital of Harbin Medical University,Harbin,China
摘要：BACKGROUND Blood glucose and serum albumin have been associated with cardiovascular disease prognosis,but the impact of admission-blood-glucose-to-albumin ratio(AAR)on adverse outcomes in critical ill coronary artery disease(CAD)patients was not investigated.
METHODS Patients diagnosed with CAD were non-consecutively selected from the MIMIC-Ⅳ database and categorized into qu-artiles based on their AAR.The primary outcome was 1-year mortality,and secondary endpoints were in-hospital mortality,acute ki-dney injury(AKI),and renal replacement therapy(RRT).A restricted cubic splines model and Cox proportional hazard models ass-essed the association between AAR and adverse outcomes in CAD patients.Kaplan-Meier survival analysis determined differences in endpoints across subgroups.
RESULTS A total of 8360 patients were included.There were 726 patients(8.7％)died in the hospital and 1944 patients(23％)died at 1 year.The incidence of AKI and RRT was 63％ and 4.3％,respectively.High AAR was markedly associated with in-hospital mor-tality(HR=1.587,P=0.003),1-year mortality(HR=1.502,P＜0.001),AKI incidence(HR=1.579,P＜0.001),and RRT(HR=1.640,P＜0.016)in CAD patients in the completely adjusted Cox proportional hazard model.Kaplan-Meier survival analysis noted substa-ntial differences in all endpoints based on AAR quartiles.Stratified analysis and interaction test demonstrated stable correlations bet-ween AAR and outcomes.
CONCLUSIONS The results highlight that AAR may be a potential indicator for assessing in-hospital mortality,1-year mortal-ity,and adverse renal prognosis in critical CAD patients.
机标关键词：insightsglucosedatabaseprognosisalbuminimpactbloodwith
论文发表日期：2025-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 563-577 )