Postdischarge cancer and mortality in patients with coronary artery disease:a retrospective cohort study
Yi-Hao WANG1
Shao-Ning ZHU1
Ya-Wei ZHAO1
Kai-Xin YAN1
Ming-Zhuang SUN1
Zhi-Jun SUN2
Yun-Dai CHEN2
Shun-Ying HU2
1.Senior Department of Cardiology,the Sixth Medical Center,Chinese PLA General Hospital,Beijing,China;Medical School of Chinese PLA,Beijing,China2.Senior Department of Cardiology,the Sixth Medical Center,Chinese PLA General Hospital,Beijing,China
摘要：BACKGROUND Our understanding of the correlation between postdischarge cancer and mortality in patients with coronary ar-tery disease(CAD)remains incomplete.The aim of this study was to investigate the relationships between postdischarge cancers and all-cause mortality and cardiovascular mortality in CAD patients.
METHODS In this retrospective cohort study,25％ of CAD patients without prior cancer history who underwent coronary art-ery angiography between January 1,2011 and December 31,2015,were randomly enrolled using SPSS 26.0.Patients were monitor-ed for the incidence of postdischarge cancer,which was defined as cancer diagnosed after the index hospitalization,survival status and cause of death.Cox regression analysis was used to explore the association between postdischarge cancer and all-cause morta-lity and cardiovascular mortality in CAD patients.
RESULTS A total of 4085 patients were included in the final analysis.During a median follow-up period of 8 years,174 patien-ts(4.3％)developed postdischarge cancer,and 343 patients(8.4％)died.A total of 173 patients died from cardiovascular diseases.Postdischarge cancer was associated with increased all-cause mortality risk(HR=2.653,95％ CI:1.727-4.076,P＜0.001)and cardiov-ascular mortality risk(HR=2.756,95％ CI:1.470-5.167,P=0.002).Postdischarge lung cancer(HR=5.497,95％ CI:2.922-10.343,P＜0.001)and gastrointestinal cancer(HR=1.984,95％ CI:1.049-3.750,P=0.035)were associated with all-cause mortality in CAD pati-ents.Postdischarge lung cancer was significantly associated with cardiovascular death in CAD patients(HR=4.979,95％ CI:2.114-11.728,P＜0.001),and cardiovascular death was not significantly correlated with gastrointestinal cancer or other types of cancer.
CONCLUSIONS Postdischarge cancer was associated with all-cause mortality and cardiovascular mortality in CAD patients.Co-mpared with other cancers,postdischarge lung cancer had a more significant effect on all-cause mortality and cardiovascular mort-ality in CAD patients.
机标关键词：cancerstudywitharterycohortcoronarydiseasemortality
论文发表日期：2025-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 578-586 )