The prognostic significance of the fibrosis-5 index in patients with acute decompensated heart failure
Sefa Tatar1
Yunus Emre Yavuz2
Hilal Nur Gedik1
Abdullah Içli1
Hakan Akilli1
1.Department of Cardiology,Meram Faculty of Medicine,Necmettin Erbakan University,Konya,Turkey2.Department of Cardiology,T.C.Ministry of Health Siirt Training and Research Hospital,Siirt,Turkey
摘要：BACKGROUND Acute decompensated heart failure(ADHF)is one of the leading causes of mortality,highlighting the import-ance of early identification of high-risk patients.The fibrosis-5(FIB-5)index,traditionally used to evaluate hepatic fibrosis,may ho-ld prognostic value in ADHF patients by reflecting systemic congestion,inflammation,and organ dysfunction.The hypothesis of th-is study is that the FIB-5 index is an independent predictor of 1-month mortality in patients with ADHF.
METHODS This retrospective study included 155 patients diagnosed with ADHF between 2020 and 2024.Patients were divid-ed into two groups based on their left ventricular ejection fraction(LVEF ≤ 40％ or LVEF＞50％).Survival was monitored for one mo-nth,and clinical,biochemical,and echocardiographic parameters were compared between survivors and death.Logistic regress-ion and receiver operating characteristic curve analyses were performed to assess the prognostic value of the FIB-5 index.
RESULTS During the 1-month follow-up,66 patients(42.6％)died.The mean FIB-5 index was significantly lower in non-surviv-ors(-10.46±6.93)compared to survivors(-8.10±6.67)(P=0.03).Multivariate regression analysis identified the FIB-5 index as an independent predictor of 1-month mortality(OR=1.089,95％ CI:1.022-1.160,P=0.009).The receiver operating characteristic cur-ve analysis demonstrated an area under the curve of 0.609(95％ CI:0.51-0.699)with sensitivity of 59.6％ and specificity of 63.4％.Ka-plan-Meier survival analysis revealed significantly higher mortality rates among patients with lower FIB-5 values(log-rank:7.887,P=0.005).
CONCLUSIONS The FIB-5 index is an independent predictor of 1-month mortality in ADHF patients.Its low cost,non-invasive nature,and ability to reflect systemic inflammation and congestion make it a promising tool for risk stratification.Prospective stu-dies are needed to validate its utility in clinical practice and evaluate its role in guiding therapeutic decisions.
机标关键词：significanceheartindexwithacutedecompensatedfailurefibrosis-5
论文发表日期：2025-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 587-595 )