Cognitive function disparities among atrial fibrillation patients with varying comorbidities
Mei-Qi ZHAO1
Ting SHEN1
Man-Lin ZHAO1
Jia-Xin LIU2
Mei-Lin XU3
Xin LI1
Liu HE1
Yu KONG1
Chang-Sheng MA1
1.Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,National Clinical Research Center for Cardiovascular Diseases,Beijing,China2.Department of Cardiology,Beijing Shunyi Hospital,Beijing,China3.Departm-ent of Cardiology,Beijing Yanqing District Hospital(Peking University Third Hospital Yanqing Hospital),Beijing,China
摘要：BACKGROUND Mild cognitive impairment(MCI)is common in atrial fibrillation(AF)patients and may develop earlier in those with multiple cardiovascular comorbidities,potentially impairing self-management and treatment adherence.This study aimed to characteri-ze the prevalence and profile of MCI in AF patients,examine its associations with cardiovascular comorbidities,and assess how these com-orbidities influence specific cognitive domains.
METHODS This cross-sectional study analyzed data from AF patients who underwent cognitive assessment between 2017 and 2021.Cognitive status was categorized as MCI or non-MCI based on the Montreal Cognitive Assessment.Associations between comorbiditi-es and MCI were assessed by logistic regression,and cognitive domains were compared using the Mann-Whitney U test.
RESULTS Of 4136 AF patients(mean age:64.7±9.4 years,64.7％male),33.5％of patients had MCI.Among the AF patients,31.2％of pat-ients had coronary artery disease,20.1％of patients had heart failure,and 18.1％of patients had hypertension.88.7％of patients had left atrial enlargement,and 11.0％of patients had reduced left ventricular ejection fraction.Independent factors associated with higher MCI prevalence included older age(OR=1.04,95％CI:1.03-1.05,P＜0.001),lower education level(OR=1.51,95％CI:1.31-1.73,P＜0.001),hyp-ertension(OR=1.28,95％CI:1.07-1.52,P=0.001),heart failure(OR=1.24,95％CI:1.04-1.48,P=0.020),and lower left ventricular ejecti-on fraction(OR=1.43,95％CI:1.04-1.98,P=0.028).A higher CHA2DS2-VASc score(OR=1.27,95％CI:1.22-1.33,P＜0.001;≥ 2 points vs.＜2 points),and greater atherosclerotic cardiovascular disease burden(OR=1.45,95％CI:1.02-2.08,P=0.040;2 types vs.0 type)were link-ed to increased MCI risk.These above factors influenced various cognitive domains.
CONCLUSIONS MCI is common in AF and closely associated with cardiovascular multimorbidity.Patients with multiple comorbid-ities are at higher risk,highlighting the importance of routine cognitive assessment to support self-management and integrated care.
机标关键词：cognitivefunctionwithamongatrialcomorbiditiesdisparitiesfibrillation
论文发表日期：2025-10-30
在线出版日期：2025-11-19（本平台首次上网日期，不代表文献的发表时间）
页数：12( 859-870 )