Changes of Apoptosis in Rats of Acute Ischemic Renal Injury under Treatment of Tetrandrine
钱玲梅1
王笑云2
冷静3
1.Department of Emergence Medicine,Deparment of Nephrology,the First Affiliated Hospital of Nanjing Medical University,Nanjing Jiangsu 210029,P.R.China;Department of Emergence Medicine,Department of Pathology,Nanjing Medical University,Nanjing Jiangsu 210022.Department of Emergence Medicine,Deparment of Nephrology,the First Affiliated Hospital of Nanjing Medical University,Nanjing Jiangsu 210029,P.R.China3.Department of Emergence Medicine,Department of Pathology,Nanjing Medical University,Nanjing Jiangsu 210029,P.R.China
摘要：ObjectiveTo elucidate the effect of tetrandrine on acute ischemic renal injury and its relation with apoptosis.MethodsA model for bilateral post-ischemic renal injury in rats was developed by clamping renal pedicles for 45 min.Renal tissular DNA fragmentation analysis and renal tissular HE staining were used.Also quantitative analysis of apoptosis in injured renal tubular epithelium was carried out by using TdT-mediated dUTP nick and labeling (TUNEL).ResultsApoptosis of renal tubular epithelium increased in acute ischemic renal injury.Tetrandrine could remarkably decrease the level of apoptosis in injured renal tubule while protecting renal tissue against the ischemic injuries.ConclusionTetrandrine could adjust the level of apoptosis in renal tubular epithelium and alleviate renal tissular injury.``
机标关键词：
分类号：R9(药学)
资助基金：教学改革项目(NY97055)
论文发表日期：2002-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 6-11 )
英文信息