Perioperative Changes of Plasma Endothelin-1 in Patients Undergoing Coronary Artery bypass Grafting and the Effect of Nitroglycerin
陈鑫
蒋英硕
徐明
陈振强
郭子黄
1.Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital Affiliated of NJMU, Nanjing 210006, P. R. China2.Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital Affiliated of NJMU, Nanjing 210006, P. R. China3.Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital Affiliated of NJMU, Nanjing 210006, P. R. China4.Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital Affiliated of NJMU, Nanjing 210006, P. R. China5.Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital Affiliated of NJMU, Nanjing 210006, P. R. China
摘要：Objectioe To observe the dynamic changes of the plasma ET-1 and the effect of low dose nitroglycerin in patients with coronary artery bypass surgery. Methods Forty patravenous nitroglycerin 1 μg @ kg-1 @ rain-1 perioperatively. RIA was used to assay the plasma ET-1 lev-el. All the hemodynamie parameters were recorded by the Swan-Ganze catheter. Results The preoperative plasma ET-1 level in patients with coronary artery disease was significantly higher than the normal level. Five minutes after cardiopalmouary bypass in these patients the plasma ET-1 level was increased significantly until 6 to 8 h after operation. The increasing plasma ET-1 level in group B was less intense than that in group A. There was a positive correlation between the plasma ET-1 level and the mean pulmonary artery pressure in group A 2 and 8 h after operation. Conclusion In patients undergoing coronary artery bypass surgery, the increased plasma ET-1 level may be due to the influence of cardiopulmonary bypass partly. Low dose nitroglycerin is beneficial to these patients.
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分类号：R3(基础医学)
论文发表日期：2002-04-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 65-68 )
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