The Relationship of Insulin-receptor Gene Polymorphism to Ischemic Stroke?
张颖冬
石铸
刘阳
1.Department of Neurology, the Affiliated Brain Hospital of NJMU, Nanjing 210029, P. R. China2.Department of Neurology, the Affiliated Brain Hospital of NJMU, Nanjing 210029, P. R. China3.Department of Neurology, the Affiliated Brain Hospital of NJMU, Nanjing 210029, P. R. China
摘要：Objective To investigate the role of mutation of insulin-receptor ( INSR ) gene in the development of ischemic stroke. Methods The base-variations at exoa 17 and 20 of INSR gene, by means of PCR-SSCP were determined in 68 cases of atherothrombotic cerebral infarction (ACI), 81 cases of lacunar infarction (LI) and 62 healthy controls (HC). Results There were 2 alleles of T and C at exoa 17 of INSR gene. The prevalence of mutant of T allele in ACI patients was more common than that in the controls. The blood pressure and the parameters of lipid metabolism in the patients with mutant were higher than those in the controls with wild-type gene. However, the correlative analysis showed that the polymorphism of INSR gene was not related statistically to the blood pressure. No base-variation at exon 20 was found in the study. Conclusion The mutation at exon 17 of INSR gene, by promoting the development of atherosclerosis, may participate in the occurrence of ischemic stroke.
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分类号：R3(基础医学)
论文发表日期：2002-04-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 69-74 )
英文信息