The Antiandrogen Withdrawal Syndrome
华立新
吴宏飞
眭元庚
程双管
徐正铨
张炜
钱立新
1.Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P. R. China2.Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P. R. China3.Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P. R. China4.Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P. R. China5.Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P. R. China6.Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P. R. China7.Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P. R. China
摘要：Objective To evaluate the response to antiandrogen withdrawal in patients with advanced prostate cancer treated with combined androgen blockade. Methods Twenty-four cases of advanced prostate cancer (10 in stage C and 14 in stage D) were retrospectively studied. All the patients were treated with combined androgen blockade (bilateral orchiectomy and flutamide ). After initial response to hormone therapy for 7 to 36 months, flutamide was discontinued because of deterioration of the disease. Serum prostate specific antigen ( PSA ) levels were checked every 2 to 4 weeks and symptoms observed. Results The results following withdrawal of flutamide were as follows: 8 patients showed a decline in PSA (mean 7 4. 8 o% ), of whom 6 cases had the PSA decline greater than 5 0 %. Clinical symptoms improved in 4 cases. The nodules of the prostate were smaller than before in cases. The mean duration of response was 4. 3 months. Conclusion In patients with hormone refractory advanced prostate cancer after initial combined androgen blockade therapy, a trial of "antiendrogen withdrawal" is a reasonable choice of therapeutic maneuver.
机标关键词：
分类号：R3(基础医学)
论文发表日期：2002-04-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 85-87 )
英文信息