Gender Difference of Cadmium-induced Renal Tubular Dysfunction for Inhabitants in Toyama,Japan
蔡云清1
AOSHIMA Keiko2
KATOH Terutaka2
TERANISHI Hidetoyo2
KASUYA Minoru2
1.Department of Nutrition and Food Science,School of Public Health,Nanjing Medical University , Nan-jing, 210029, P. R. China2.Department of Public Health, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 930-01,Japan
摘要：Objective The aim of the present study was to compare the gender differencefor cadmium-induced renal tubular dysfunction between the male and female inhabitants. MethodsUrinary β2-microglobulin was measured in 299 male (94%) and 342 female (92%) inhabitants aged54 - 72 years,and the development of renal tubular dysfunction for 11 years was studied in the 62married couples from them. Results A significantly higher cumulative incidence was found in bothmen and women in cudmium-polluted area,showing 68. 4% in men and 64.8% in women compared to15.3 % in men and 5.9 % in women in the reference areas. Relative risk of renal tubular dysfunctionin females (11.0) was higher than males (4.5). The ratios of urinary β2-nicroglobulin and glucosewere higher in women than those in men in both the cadmium-polluted areas and the reference areas.Conclusion Although almost identical incidences were detected between men and wonen, the changesin excretion of β2-microglobulin and glucose was greater in women than those in men. These findings sug-gest that renal tubular dysfunction might be more progressive in women than that in men.
机标关键词：
分类号：R3(基础医学)
资助基金：教育部科学技术研究项目(B.09480121)
论文发表日期：2002-10-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 156-162 )
英文信息