Alteration of Excitatory Amino Acid in Experimental Spinal Cord Injury in Rats
张宁1
罗永湘2
1.Department of Orthopaedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing,2100292.Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430030,P. R. China
摘要：Objective To detect the effect of excitatory amino acid (EAA) in the sec-ondary damage following spinal cord injury (SCI). Methods Glutamate (Glu) and Aspartate(Asp) on the injury site (T8) were studied using a rat SCI model induced by Allen's weight drop method(10g×2.5cm). The result suggested that Asp and Glu were significantly increased in 10 min. Re-sults Glu was significantly decreased from 2 h to 24 h,while Asp was a little reduced in 2 h,andslightly rose in 4 h as compared with Control Group. Though elevated in 8 h, it dropped again in 24 h ascompared with Control Group. Conclusion The result indicates that the rise of EAA following SCIcould be the cause of the secondary spinal cord damage.
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分类号：R3(基础医学)
论文发表日期：2002-10-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 179-181 )
英文信息