Review of the Mechanisms of Action of the Statins and Their PleiotropicEffects in the Treatment of Hypercholesterolemia and Atherosclerosis
MODUTLWA Dawson Nkaelang
LI Zhi-you
YOU Qi-dong
摘要：Statins are lipid-lowering agents widely used in the treatment of hypercholesterolemia and atherosclerosis. They act by inhibiting of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme responsible for the conversion of HMG-CoA to mevalonate in cholesterol biosynthesis. Due to their ability to reduce Iow-density lipoproteins (LDL) levels more than other cholesterol-lowering drugs, they have become the drugs most often prescribed in the treatment of atherosclerosis.
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分类号：R5(内科学)
论文发表日期：2004-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 48-51 )
英文信息