Monocyte chemoattractant protein-1 plays a key role in type 1 diabetes
Dong Li
Guoliang LIU
摘要：Type 1 diabetes is an autoimmune disease resulting from the selective destruction of β cells in the pancreatic islets.In both human and rodent models of type 1 diabetes, the clinical disease is preceded by a progressive mononuclear cell invasion of the pancreatic islets (insulitis). In the early stage of insulitis, the major components are monocyte/macrophages, and the recruitment of mononuclear cells is a critical step in the pathogenesis of the type 1 diabetes. Studies have revealed that Monocyte chemoattractant protein-1(MCP-1)specifically recruits monocytes/macrophages into pancreas and plays an important role in the development of insulitis and diabetes.
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论文发表日期：2005-03-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 60-62 )
英文信息