Analysis of T-lymphocyte subtypes of the peripheral blood and skin delayed-type hypersensitivity in patients with hyper-IgE syndrome
Xiaobing Lei
Shengshun Tan
Weihui Zeng
Junmin Wang
Panjian Zhang
Yuan Yuan
摘要：Objective: To study the function of cellular immunity in patients with hyper-IgE syndrome (HIE). Methods:T-lymphocyte subtypes of the peripheral blood and cutaneous delayed-type hypersensitivity (DTH) response to two recall antigens, tetanus toxoid (TT) and purified protein derivative(PPD), were measured in five patients with HIE and 15 healthy controls, respectively. Results: The CD4+ cell counts in HIE group were significantly lower than those in control group ( P ＜ 0.01). In contrast, CD8 + cells were significantly higher than those in the control ( P ＜ 0.01). The induration sizes of DTH response to two recall antigens were smaller in HIE group than those in the control group ( P ＜ 0.01 ). Conclusion: There was an immunologic dysfunction of T lymphocytes in the patients with HIE.
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论文发表日期：2005-03-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 99-101 )
英文信息