Expressions of IL-10 on leukemic cells in acute leukemic patients and its significance
Yun Yang
Wanggang Zhang
Yichao Qiao
yinxia Chen
Xingmei CAO
摘要：Objective: To explore the expressions of IL-10 on leukemic cells in acute leukemia patients and its significance.Methods: The expressions of IL-10 on leukemic cells in thirty patients was measured by indirect immunofluorescence technique. Results:Observed yellow-green bright fluorescence on leukemic cells membrane, the positive rate of cells was 10-80%, there were 18 patients expressing IL-10 (18/30, 60%) positively, among them 11 with ANLL (11/19, 58%) and 7 with ALL (7/11, 64%) respectively while that of peripheral mononucleate cells in control group was 13 %. Compared with that in the control group, there was a significant increase of positive rate in ANLL and ALL but with no significant difference between ANLL and ALL. Conclusion: IL-10 secreted by leukemic cells, contributed to the immunosuppressive state at the tumor site. This is probably one of the important mechanisms of acute leukemic escape.
机标关键词：
分类号：R733(造血器及淋巴系肿瘤)
论文发表日期：2005-05-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 135-138 )
英文信息