Quantitative MR application in depression model of rats: a preliminary study
Wei Wang
Wenxun Li
Fang Fang
HAO Lei
Xiaoping Yin
Jianpin Qi
Baiseng Wang
Chengyuan Wang
摘要：Objective: To investigate findings and value of quantitative MR in depression model of rats. Methods: Twenty male SD rats were divided into model group and control group randomly (10 rats in each group). The depression model of rats was erected by separation and chronic unpredictable stress. The behavior of rat was detected by open-field test and sucrose consumption. The MR images of brain tissues were produced in vivo rats with T2-and diffusion-weighted imaging. The changes of body weight and behavior score and thevalues of T2 and ADC of ROIs were compared between the two groups. Histological verification of hippocampal neuron damage was alsoperformed under ultramicrosopy. Results: Compared with the control group, T2 values in hippocampus prolonged 5.5 % ( P ＜ 0.05),ADC values in hippocampus and in temporal lobe cortex decreased 11.7 % and 10.9% (P ＜ 0.01)respectively in the model group. Histo-logic data confirmed severe neuronal damage in the hippocampus of the model group. Conclusion: This study capitalized on diffusion-weighted imaging as a sensitive technique for the identification of neuronal damage in depression and it provides an experimental evidence ofMRI in depression investigation and clinical application.
机标关键词：
分类号：R54(心脏、血管（循环系）疾病)
论文发表日期：2005-05-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 152-155 )
英文信息