Experimental study of changes of TNF-α in rabbits with steroid-induced avascular necrosis of femoral head
Puwei Yuan
Xijing He
Dong Wang
HaoPeng Li
Binshang Lan
Huiru Lu
摘要：Objective: To explore the effect of tumor necrosis factor-α(TNF-α)on the occurrence of steroid-induced avascular necrosis of femoral head(SANFH). Methods: Twenty-four rabbits were firstly divided into void group ( n = 12) and model group ( n =two groups were killed respectively to observe whether the model was successful. The level of TNF-α in serum of the residual rabbits of the two groups was examined in Radioimmunoassay method. Results: The level of TNF-α in model group is significantly higher than that in void group( P ＜0.001) under the premise of the model of SANFH success by histological observation. Conclusion: The rise of level of TNF-α may be one of the most important factors in the occurrence of SANFH.
机标关键词：
分类号：R68(骨科学（运动系疾病、矫形外科学）)
资助基金：山西省中医药管理局资助项目(99017)
论文发表日期：2005-05-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 161-163 )
英文信息