Effects of Bushen Zhuanggu Formul on interleukin-6 production and bone metabolism of the ovariectomized rats
Lulu Chen
Huiqing Li
Tianshu Zeng
Wenfang Xia
Juan Zheng
Min Zhou
摘要：Objective: To observe the effects of Bushen Zhuanggu Formul on interleukin 6 (IL-6) level and bone metabolism of the ovariectomized rats, and to explore the possible mechanism of preventing and treating postmenopausal osteo porosis by traditional Chinese Formul. Methods: SD rats were randomly divided into 4 groups: normal control group (N),ovariectomized control group (OVX), estrogen-treated group (OVX+E) traditional and Chinese medicine-treated group (OVX+CM). After treatment, IL-6 levels in rat bone tissue media and serum were examined by ELISA. The proximal tibias(PTM) of rats were undecalcified for quantitative bone histomorphometry. Results: Compared with OVX group, both Bushen Zhuanggu medicine and estrogen decreased IL-6 level in rat bone tissue media. However, the effects of Bushen Zhuanggu Formul were weaker than those of estrogen. Furthermore, Bushen Zhuanggu Formul and estrogen produced a reduction in bone turnover by inhibiting bone formation and bone resorption at the same time. Conclusion: Bushen Zhuanggu Formul prevents ovariectomic bone loss by inhibiting IL-6 production in rat bone tissues.
机标关键词：
分类号：R6(外科学)
资助基金：国家自然科学基金(39770930)
论文发表日期：2006-07-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 193-196 )
英文信息