Effects of simulated microgravity on antioxidant system in testis of adult rats
Dangxia Zhou
Shudong Qiu
Ying Sun
Jie Zhang
Haixue Wang
摘要：Objective: To study the effects of simulated microgravity induced by tail-suspension on histological structures and antioxidant system in testis of adult rats. Methods: Forty Spraque-Dawley adult male rats were randomly divided into four groups, two experimental groups and two synchronic control groups. Rats in the two experimental groups were tail-suspended for 14 d and 28 d respectively, then serum hormone, testicular morphology and biochemical changes were evaluated. Results:Compared with the synchronic controls, serum testosterone (T) levels and testicular superoxide dismutase (SOD) significantly decreased(P ＜ 0.05), while testicular malondialdehyde(MDA) significantly increased (P ＜ 0.05) in tail-suspended rats. The changes were more prominent in the 28 d tail-suspended rats. In addition, hematoxylin and eosin (HE) staining showed that seminiferous tubules atrophied, spermatogenic cells decreased, and seminiferous epithelial cells disintegrated and shed, abnormal multinucleated giant cells appeared and the lumina were azoospermic in tail-suspended rats. Conclusion: Simulated microgravity induced by tailsuspension has a harmful effect on male reproduction of adult rats by decreasing the ability of testicular antioxidant defense.
机标关键词：
分类号：R3(基础医学)
资助基金：陕西省科技计划(2005K15-G2)教学改革项目(573026)
论文发表日期：2006-07-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 234-237 )
英文信息