Effects of bone morphogenetic protein on the osseointegration of porous-surfaced implants: An experimental study in rabbits
Yimin Ma
Weimin Fan
Yu Zhang
摘要：Objective: Research on enhancing early osseointegration of cementless implants to improve early fixation and reducing of risk of loosening. Methods: Thirty New Zealand rabbits were divided into two groups at random. BMP combined with DBM 30 mg was inserted around the prosthesis in 15 rabbits as experimental group, the remaining rabbits were served as control group. After 4, 8, and 12 weeks, five rabbits were sacrificed in each group. The humerus with the implants were retrieved.Bone ingrowth was analyzed by none-decalcification bone ground section and biomechanical test. Results: At the end of 4 and 8weeks the osseointegration rates of BMP group were higher than those of control (P ＜ 0.05). The ultimate shear strength between BMP treated implantation and the control was the same as the results in osseointegration rates at 4, 8 weeks (P ＜ 0.05). However,there was no difference between the treated and untreated group in the osseointegration rate and ultimate shear strength at 12 weeks (P ＞ 0.05). Conclusion: BMP combination can enhance bone growth into gaps around cementless implants, especially in the early postoperative period.
机标关键词：
分类号：R3(基础医学)
资助基金：教学改革项目(2001)
论文发表日期：2006-11-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 335-340 )
英文信息