Comparative study of effects of bone marrow cell vs. Ad5-HGF administration via non infarct-related artery injection in myocardial infarction in swine
Liansheng Wang
Zhijian Yang
Wei Wang
Dongchao Ma
Shunlin Xu
Yuqing Zhang
Fang Zhou
Bo Chen
Kejiang Cao
Jun Huang
摘要：Objective: To evaluate the effect of transplanting bone marrow-derived mesenchymal stem cells (BM-MSCs) or adenovirus5-hepatocyte growth factor(Ad5-HGF) via non-infarct-related artery injection in swine myocardial infarction models. Methods :BMMSCs were obtained from swine bone marrow and expanded in vitro to a purity of ＞50%. A myocardial infarction(MI) was created by ligating the distal left anterior descending artery in swine. Either BM-MSCs (5 × 106/ml) or Ad5-HGF (4 × 109 pfu) were transfused via the right coronary artery (non-infarcted artery) four weeks after MI. Gate-controled cardiac perfusion imaging was performed at the end of four and seven weeks after LAD ligation, to evaluate heart function and cardiac perfusion. Morphologic and histologic characteristics of the hearts were also studied. Results: (1)The gate-controlled cardiac perfusion imaging showed that the improvement in LVEF was greater in both treatment groups than in control group at the 4th weeks. (2)In both treatment groups, capillary density was significantly higher than that of control group (P ＜ 0.05). Conclusion:BM-MSCs or Ad5-HGF transplantation via non-infarcted artery administration can stimulate angiogenesis and improve heart function, but there was no difference in therapeutic efficacy between BM-MSCs and Ad5-HGF.
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分类号：R5(内科学)
论文发表日期：2007-03-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 72-76 )
英文信息